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TranscriptomicsAnalysis of mouse T cell transcription profile after co-culture with BaF3 cells with or without the oncogenic point mutation JAK2 V617F
The activation of PD-1 (Programmed Death receptor-1) on T cells can cause T cell exhaustion and immune tolerance. Some tumors up-regulate the expression of the ligand of PD-1, namely PD-L1 (Programmed Death Receptor-Ligand 1), thus preventing anti-tumor immune response and promoting immune-escape. P...
ORGANISM(S): Mus musculus 
2018-12-01 | E-MTAB-5028 | biostudies-arrayexpress
TranscriptomicsMurine Ba/F3 Cells: Ba/F3 cells expressing wild type JAK2 (WT cells) vs. Ba/F3 cells expressing JAK2 V617F mutant (VF cells)
Transcriptional profiling of transformed Ba/F3 cells by myeloproliferative neoplasm-associated JAK2 V617F mutant comparing control Ba/F3 cells expressing wild type JAK2. Two-condition experiment, WT cells vs. VF cells. One replicate per array.
ORGANISM(S): Mus musculus 
2013-10-31 | E-GEOD-34239 | biostudies-arrayexpress
TranscriptomicsGenetic variation at MECOM, TERT, JAK2 and HBS1L-MYB predispose to myeloproliferative neoplasms
Genome-wide association study of JAK2 V617F negative myeloproliferative neoplasms consisting of 524 cases at stage 1
ORGANISM(S): Homo sapiens 
2015-02-20 | E-MTAB-3340 | biostudies-arrayexpress
GenomicsEffects of the treatment with pegIFNa, Azacytidine or pegIFNa+Azacytidine in LT-HSCs from JAK2-V617F MPN mice or JAK2-V617F Dnmt3a-KO MPN mice.
Effects of the treatment with pegIFNa, Azacytidine or pegIFNa+Azacytidine in LT-HSCs from JAK2-V617F MPN mice or JAK2-V617F Dnmt3a-KO MPN mice.
PRJNA1074267 | ENA
GenomicsHematopoietic Stem Cell Heterogeneity in JAK2 V617F+ Essential Thrombocythemia
Hematopoietic Stem Cell Heterogeneity in JAK2 V617F+ Essential Thrombocythemia
PRJNA436952 | ENA
GenomicsGene expression profile at single cell level of phenotypic LT-HSCs from single-mutant JAK2 V617F and double mutant JAK2 V617F Dnmt3a-/- mice
Gene expression profile at single cell level of phenotypic LT-HSCs from single-mutant JAK2 V617F and double mutant JAK2 V617F Dnmt3a-/- mice
PRJNA938038 | ENA
TranscriptomicsEffects of the treatment with pegIFNa, Azacytidine or pegIFNa+Azacytidine in LT-HSCs from JAK2-V617F MPN mice or JAK2-V617F;Dnmt3a-KO MPN mice.
Pegylated interferon alpha (pegIFNα) can induce molecular remissions in JAK2-V617F-positive myeloproliferative neoplasms (MPN) patients by targeting long-term hematopoietic stem cells (LT-HSCs). Additional somatic mutations in genes regulating LT-HSC self-renewal, such as DNMT3A, have been reported ...
ORGANISM(S): Mus musculus 
2024-03-29 | GSE255253 | GEO
GenomicsProinflammatory phenotype of iPS cell-derived JAK2 V617F megakaryocytes induces fibrosis in 3D in vitro bone marrow niche
Proinflammatory phenotype of iPS cell-derived JAK2 V617F megakaryocytes induces fibrosis in 3D in vitro bone marrow niche
PRJNA948027 | ENA
ProteomicsTargeting JAK2-V617F stability through TRIM4 recruitment reveals a therapeutic vulnerability in myeloproliferative neoplasms
JAK2-V617F is a key oncogenic driver in myeloproliferative neoplasms (MPNs), yet mechanisms governing its protein stability and strategies for its degradation remain incompletely understood. Here, we employed an integrated screening strategy combining deubiquitinase and E3 ligase functional librarie...
ORGANISM(S): Homo Sapiens 
PXD083051 |
TranscriptomicsGene expression profile at single cell level of phenotypic LT-HSCs from single-mutant JAK2 V617F and double mutant JAK2 V617F;Dnmt3a-/- mice
We investigated if Dnmt3a loss leads to alterations in JAK2 V617F LT-HSCs heterogenity and expression profile using single-cell RNA sequencing.
ORGANISM(S): Mus musculus 
2024-03-29 | GSE225918 | GEO
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