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UnknownDifferentiation of Prior SARS-CoV-2 Infection and Postacute Sequelae by Standard Clinical Laboratory Measurements in the RECOVER Cohort.

Background

There are currently no validated clinical biomarkers of postacute sequelae of SARS-CoV-2 infection (PASC).

Objective

To investigate clinical laboratory markers of SARS-CoV-2 and PASC.

Design

Propensity score-weighted linear regression models were fitted to evaluate d...
S-EPMC11408082 | biostudies-literature
TranscriptomicsTranscription profiling of human myelogenous leukemia K562 cells expressing BASP1
We have analysed the dynamic between WT1 and BASP1 in the regulation of gene expression in myelogenous leukaemia K562 cells. Our analysis reveals that BASP1 is a significant regulator of WT1 that is recruited to WT1-binding sites and suppresses WT1-mediated transcriptional activation at several WT1 ...
ORGANISM(S): Homo sapiens 
2010-12-18 | E-MEXP-2573 | biostudies-arrayexpress
UnknownGenome-wide association analysis identifies ancestry-specific genetic variation associated with acute response to metformin and glipizide in SUGAR-MGH.

Aims/hypothesis

Characterisation of genetic variation that influences the response to glucose-lowering medications is instrumental to precision medicine for treatment of type 2 diabetes. The Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans (SUGAR-MG...
S-EPMC10790310 | biostudies-literature
TranscriptomicsEffects of pregnancy and progesterone supplementation on endometrial gene expression in cattle
An increase in circulating progesterone (P4) concentrations is associated with increased pregnancy success in beef and dairy cattle. Our objective was to ascertain differential effects of elevated P4 concentrations following conception on endometrial gene expression in beef heifers on Days 5, 7, 13 ...
ORGANISM(S): Bos taurus 
2011-10-17 | E-GEOD-33030 | biostudies-arrayexpress
UnknownEffect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial.

Background

Hyperglycaemia is associated with increased risk of cardiovascular complications in people with type 2 diabetes. We investigated whether reduction of blood glucose concentration decreases the rate of microvascular complications in people with type 2 diabetes.

Methods

ACCORD...
S-EPMC4123233 | biostudies-literature
TranscriptomicsSingle Cell RNAseq from IL6R deficient patient and healthy parent
To determine the phenotypic differences in blood cells that are regulated by the IL-6R
ORGANISM(S): Homo sapiens 
2019-06-19 | E-MTAB-8034 | biostudies-arrayexpress
UnknownThe effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): a randomised placebo-controlled trial.

Background

Lowering LDL cholesterol with statin regimens reduces the risk of myocardial infarction, ischaemic stroke, and the need for coronary revascularisation in people without kidney disease, but its effects in people with moderate-to-severe kidney disease are uncertain. The SHARP trial ...
S-EPMC3145073 | biostudies-literature
UnknownMultiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study.

Introduction

The multiorgan impact of moderate to severe coronavirus infections in the post-acute phase is still poorly understood. We aimed to evaluate the excess burden of multiorgan abnormalities after hospitalisation with COVID-19, evaluate their determinants, and explore associations wi...
S-EPMC7615263 | biostudies-literature
TranscriptomicsIdentification of Beef Heifers with Superior Uterine Capacity for Pregnancy
Infertility and subfertility represent major problems in domestic animals and humans, and the majority of embryonic loss occurs during the first month of gestation that involves pregnancy recognition and conceptus implantation. The critical genes and physiological pathways in the endometrium that me...
ORGANISM(S): Bos taurus 
2016-05-15 | E-GEOD-81449 | biostudies-arrayexpress
UnknownA modified Delphi exercise in physician-perceived risk factors for drug-induced pneumotoxicity in patients with rheumatological disease.

Background

Drugs used to treat rheumatic disease are associated with pneumotoxicity (drug-induced lung disease), but little is known about associated risk factors.

Aim

To determine expert physician-perceived risk factors for developing pneumotoxicity in patients with rheumatologic con...
S-EPMC11529426 | biostudies-literature
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