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TranscriptomicsCytotoxic effects of Bortezomib in Myelodysplastic syndrome/Acute Myeloid Leukemia depend on autophagy-mediated lysosomal degradation of TRAF6 and repression of PSMA1
Bortezomib (VelcadeM-BM-)) is widely used for the treatment of various human cancers, however, its mechanisms of action are not fully understood, particularly in myeloid malignancies. Bortezomib is a selective and reversible inhibitor of the proteasome. Paradoxically, we find that Bortezomib induces...
ORGANISM(S): Homo sapiens 
2012-06-14 | E-GEOD-38519 | biostudies-arrayexpress
UnknownORTI: An Open-Access Repository of Transcriptional Interactions for Interrogating Mammalian Gene Expression Data.
Not available
S-EPMC5056720 | biostudies-literature
TranscriptomicsThe protomap is propagated to cortical plate neurons through an Eomes-dependent intermediate map
The cortical area map is initially patterned by transcription factor (TF) gradients in the neocortical primordium, which define a protomap in the embryonic ventricular zone (VZ). However, mechanisms that propagate regional identity from VZ progenitors to cortical plate (CP) neurons are unknown. Here...
ORGANISM(S): Mus musculus 
2013-04-02 | E-GEOD-43387 | biostudies-arrayexpress
UnknownMultimodality Molecular Imaging of Cardiac Cell Transplantation: Part II. In Vivo Imaging of Bone Marrow Stromal Cells in Swine with PET/CT and MR Imaging.
Not available
S-EPMC5006717 | biostudies-literature
ProteomicsThe EN-TEx Resource for Personal Functional Genomics
An overall goal of functional genomics has been to measure the impact of variants on molecular endophenotypes (e.g. gene expression levels or the degree of TF binding) and relate this to organismal traits and disease phenotypes. However, all the experiments to date have been described relative to a ...
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD022787 | Pride
Personal genomics Tmt Human Proteogenomics Tissue En-tex 
UnknownMultimodality Molecular Imaging of Cardiac Cell Transplantation: Part I. Reporter Gene Design, Characterization, and Optical in Vivo Imaging of Bone Marrow Stromal Cells after Myocardial Infarction.
Not available
S-EPMC5006716 | biostudies-literature
TranscriptomicsTranscription profiling of human lung fibroblasts exposed to vanadium pentoxide to identifiy genes associated with vanadium pentoxide-induced bronchitis
Exposure to vanadium pentoxide (V2O5) is a cause of occupational bronchitis. We evaluated gene expression profiles in cultured human lung fibroblasts exposed to V2O5 in vitro in order to identify candidate genes that could play a role in airway remodeling associated with V2O5-induced bronchitis. Gen...
ORGANISM(S): Homo sapiens 
2008-11-22 | E-GEOD-5339 | biostudies-arrayexpress
UnknownClathrin-independent carriers form a high capacity endocytic sorting system at the leading edge of migrating cells
Not available
S-JCBD-201002119 | bioimages
GenomicsEpstein-Barr Virus Exploits Intrinsic B-Lymphocyte Transcription Programs to Achieve Immortal Cell Growth
Epstein-Barr Virus Nuclear Antigen 2 (EBNA2) gene regulation through the cell RBPJ transcription factor (TF) is essential for conversion of resting B-lymphocytes (RBLs) into Lymphoblastoid Cell Lines (LCLs). ChIP-seq investigation of EBNA2 and RBPJ sites in LCL DNA found EBNA2 at 5151 and RBPJ at 10...
ORGANISM(S): Homo sapiens 
2011-07-01 | E-GEOD-29498 | biostudies-arrayexpress
UnknownA Clinical PET Imaging Tracer ([18F]DASA-23) to Monitor Pyruvate Kinase M2-Induced Glycolytic Reprogramming in Glioblastoma.
Not available
S-EPMC8639752 | biostudies-literature
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