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TranscriptomicsWhole Genome Sequencing Informs Therapeutic Selection for Pancreatic Cancer
Pancreatic cancer remains one of the most lethal of malignancies and a major health burden. We performed whole genome sequencing and CNV analysis of 100 pancreatic ductal adenocarcinomas. Chromosomal rearrangements leading to gene disruption were frequent, affecting genes known to be important in pa...
ORGANISM(S): Homo sapiens 
2015-02-27 | E-GEOD-61502 | biostudies-arrayexpress
TranscriptomicsExpression data from Control, AKT and RAS transduced cells
Mutations in both RAS and the PTEN/PIK3CA/AKT signaling module are found in the same human tumors. PIK3CA and AKT are downstream effectors of RAS, and the selective advantage conferred by mutation of two genes in the same pathway is unclear. Based on a comparative molecular analysis, we show that ac...
ORGANISM(S): Homo sapiens 
2013-03-19 | E-GEOD-45276 | biostudies-arrayexpress
TranscriptomicsGene expression in pancreatic ductal adenocarcinoma
To further develop our understanding of the gene expression signature of pancreatic ductal adenocarcinoma Gene expression signatures in macrodissected resected pancreatic ductal adenocarcinoma specimens
ORGANISM(S): Homo sapiens 
2014-03-14 | E-GEOD-55643 | biostudies-arrayexpress
ProteomicsMycobacterium tuberculosis ON-A strain (Wild type vs natural mutant)
Tuberculosis remains one of the most difficult to control infectious diseases in the world. Many different factors contribute to the complexity of this disease. These include the ability of the host to control the infection which may directly relate to nutritional status, presence of co-morbidities ...
ORGANISM(S): Mycobacterium tuberculosis 
2018-04-23 | PXD005687 | Pride
Mycobacterium tuberculosis 
TranscriptomicsEffect of short- and long-term morphine treatment on gene expression in the hypothalamus and pituitary
Addictive drugs including opioids activate signal transduction pathways that regulate gene expression in the brain. However, changes in CNS gene expression following morphine exposure are poorly understood. We studied the effect of short- and long-term morphine treatment on gene expression in the hy...
ORGANISM(S): Mus musculus 
2008-09-30 | E-GEOD-9525 | biostudies-arrayexpress
UnknownEffectiveness and safety of opicapone in Parkinson's disease patients with motor fluctuations: the OPTIPARK open-label study.
Not available
S-EPMC7055125 | biostudies-literature
UnknownTissue injury and hypoxia promote malignant progression of prostate cancer by inducing CXCL13 expression in tumor myofibroblasts.
Not available
S-EPMC4205637 | biostudies-literature
TranscriptomicsRNA-seq to investigate differentially expressed genes in KPC mouse PDAC treated with CSF-1R small molecule inhibitor AZD7507 and/or the CXCR2 small molecule inhibitor AZD5069
Recently, we defined four subtypes of pancreatic cancer that are associated with distinct histopathological characteristics and differential survival, namely, Squamous, Pancreatic Progenitor, Immunogenic, and ADEX (Bailey et al 2016, Nature). We also found that loss of CXCR2 was associated with a sw...
ORGANISM(S): Mus musculus 
2018-05-01 | E-MTAB-6620 | biostudies-arrayexpress
TranscriptomicsTranscriptomic effects of caloric restriction reflected in primate difference
Caloric restriction (CR) can delay morbidity and mortality in a broad range of species, including mice and macaques. Mutations and chemical agents, such as resveratrol or rapamycin that partly mimic the CR effect, can similarly increase survival or extend lifespan. In humans, however, the effects of...
ORGANISM(S): Pan troglodytes 
2013-02-28 | E-GEOD-44147 | biostudies-arrayexpress
UnknownSocial stress-potentiated methamphetamine seeking.
Not available
S-EPMC6375809 | biostudies-literature
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