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GenomicsConserved Function of lincRNAs in Vertebrate Embryonic Development Despite Rapid Sequence Evolution
Thousands of large intervening non-coding RNAs (lincRNAs) have been identified in mammals. To better understand the evolution and functions of these enigmatic RNAs, we used chromatin marks, poly(A)-site mapping and RNA-Seq data, to identify more than 550 distinct lincRNAs in zebrafish. Although thes...
ORGANISM(S): Danio rerio 
2011-12-22 | E-GEOD-32880 | biostudies-arrayexpress
TranscriptomicsExtensive alternative polyadenylation during zebrafish development
The post-transcriptional fate of messenger RNAs (mRNAs) is largely dictated by their 3' untranslated regions (3'UTRs), which are defined by cleavage and polyadenylation (CPA) of pre-mRNAs. We used poly(A)-position profiling by sequencing (3P-Seq) to map poly(A) sites at eight developmental stages an...
ORGANISM(S): Danio rerio 
2012-06-17 | E-GEOD-37453 | biostudies-arrayexpress
TranscriptomicsFormation, regulation and evolution of 3' UTRs in Caenorhabditis elegans
Much of posttranscriptional mRNA regulation occurs through cis-acting sequences in mRNA 3´ untranslated regions (UTRs), which interact with specific proteins and ribonucleoprotein complexes that modulate translation, mRNA stability and subcellular localization. Studies in Caenorhabditis elegans hav...
ORGANISM(S): Caenorhabditis elegans 
2010-12-24 | E-GEOD-24924 | biostudies-arrayexpress
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