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ProteomicsCSE1L and NUP37 proximity labeling in MCF10A cells expressing chimeric ErbB1:ErbB2 receptors
This project uses an MCF10A clone (B2B1) expressing chimeric synthetic receptors for ErbB1 (EGFR) and ErbB2 (HER2) along with BirA*-fused inducible alleles of CSE1L or NUP37. Cells were cultured with reconstituted basement membrane, BirA* alleles induced with doxycycline, ErbB receptors dimerized w...
ORGANISM(S): Homo sapiens (Human) 
2023-03-22 | PXD038327 | Pride
Mcf-10a Bira Breast Her2 Bioid Egfr 
TranscriptomicsOuter ECM-attached vs. inner cells of MCF10A acini at day 6 of morphogenesis
Basal-like carcinoma is a subtype of breast cancer that is characterized by poor prognosis and high intratumor heterogeneity. Using a basal-like breast epithelial line, we have identified two anti-correlated gene-expression programs that arise among single extracellular matrix (ECM)-attached cells d...
ORGANISM(S): Homo sapiens 
2015-06-05 | E-GEOD-41527 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of inducible GATA6L-overexpressing HT-29 cells stimulated with TNF
The objective of this study was to investigate the role of GATA6L with or without TNF stimulation. Microarrays were used to capture the transcriptional response to GATA6L overpexression at intermediate times after TNF stimulation. Cells were induced for GATA6L overexpression and evaluated at two hou...
ORGANISM(S): Homo sapiens 
2016-07-25 | E-GEOD-72079 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of HT-29 cells stimulated with pairwise combinations of TNF, EGF, and insulin
The objective of this study was to investigate the link between signaling-network activation and transcriptional regulation downstream of tumor necrosis factor (TNF), epidermal growth factor (EGF), and insulin. Microarrays were used to capture the transcriptional responses to TNF, EGF, and insulin a...
ORGANISM(S): Homo sapiens 
2016-07-25 | E-GEOD-69639 | biostudies-arrayexpress
ModelsPereira2020 - NRF2–p53 integrated-systems model of oxidative stress
Integrated-systems model of oxidative stress connecting NRF2 and p53 signaling pathways. Additional crosstalk linking oxidative stress to p53 inhibition, p53 to NRF2 through p21, and NRF2 to MDM2 was incorporated in this model. The NRF2 pathway was encoded as first- and second-order rate equations f...
2021-10-29 | MODEL2110270001 | BioModels
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