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TranscriptomicsGene expression profiles MCF-10A cells overexpressing MBD2
Methylated DNA binding protein 2 (MBD2) has been shown to bind specific methylated promoters and suppress transcription. Here we systematically investigate MBD2 suppression by overexpressing MBD2 in MCF-10A cells and generating gene expression profiles of overexpressing cells and normal MCF-10A cell...
ORGANISM(S): Homo sapiens 
2013-06-17 | E-GEOD-47873 | biostudies-arrayexpress
ProteomicsProteomic characterization of MDA-MB-231 and MCF-10A breast cells exposed to 1 mT 50 Hz ELF for 4 hours
MDA-MB-231 breast cancer cells and MCF-10A breast cells were exposed to 1 mT 50 Hz extremely low-frequency magnetic field (ELF-MF) for 4 hours
ORGANISM(S): Homo Sapiens (human) 
2023-02-17 | PXD040120 | JPOST Repository
Transcriptomics14-3-3ζ overexpression-induced gene signature in MCF-10A cells
To study the function of 14-3-3ζ, we established MCF-10A human mammary epithelial cells transduced with 14-3-3ζ (10A.ζ) and vector (10A.Vec) We performed gene expression profiling on 10A.ζ cells and 10A.Vec cells, and normalized to profiling of MCF-10A parental cells Total mRNA were extracted from 1...
ORGANISM(S): Homo sapiens 
2013-11-05 | E-GEOD-52032 | biostudies-arrayexpress
ProteomicsOne-pot comparative analysis and characterization of MCF-7 and MCF-10A cell lines
A comparison of different energetics based techniques for the characterization of two mammalian breast cell lines, MCF-7 a luminal A breast cancer cell line and MCF-10A a normal human breast cell line. The techniques of stability of proteins from rates of oxidation (SPROX), thermal proteome profilin...
ORGANISM(S): Homo sapiens (Human) 
2023-02-22 | PXD036268 | Pride
Thermodynamics Thermal denaturation Chemical denaturation Protein folding 
TranscriptomicsDeep sequencing of exosomal and cellular miRNAs in MDA-MB-231 and MCF-10A cells
To identify the miRNAs that are differentially expressed and secreted between the MDA-MB-231 metastatic breast cancer cells and the MCF-10A non-cancerous human mammary epithelial cells, we profiled the cellular and exosomal small RNAs (between 17 and 52 nt) isolated from these two cell lines by Sole...
ORGANISM(S): Homo sapiens 
2013-09-01 | E-GEOD-50429 | biostudies-arrayexpress
TranscriptomicsKnock-in of PIK3CA-H1047R into MCF-10A
We have compared the proteome, transcriptome and metabolome of two isogenic cell lines: MCF-10A, derived from human breast epithelium, and the mutant MCF-10A-H1047R. These cell lines differ by a single amino acid substitution (H1047R) caused by single nucleotide change in one allele of the PIK3CA ge...
ORGANISM(S): Homo sapiens 
2015-01-19 | E-GEOD-63452 | biostudies-arrayexpress
TranscriptomicsExpression data of Brti1 shRNA knockdown and control shRNA in MCF-10A cells
Homologous recombination-mediated DNA repair deficiency (HRD) predisposes to cancer development, but also provides therapeutic opportunities Here, we identified an HRD gene signature that robustly predicted HRD status Unexpectedly, concurrent loss of PTEN in BRCA1-deficient cells might extensively r...
ORGANISM(S): Homo sapiens 
2014-01-24 | E-GEOD-54264 | biostudies-arrayexpress
TranscriptomicsExpression data of BRCA1 shRNA and Rad51 shRNA knockdown and control shRNA in MCF-10A cells
Homologous recombination-mediated DNA repair deficiency (HRD) predisposes to cancer development, but also provides therapeutic opportunities. Here, we identified an HRD gene signature that robustly predicted HRD status. Unexpectedly, concurrent loss of PTEN in BRCA1-deficient cells might extensively...
ORGANISM(S): Homo sapiens 
2014-01-24 | E-GEOD-54266 | biostudies-arrayexpress
TranscriptomicsExpression data of ATM, ATR, CHK1, CHK2, and 53BP1 shRNA knockdown and control shRNA in MCF-10A cells
Homologous recombination-mediated DNA repair deficiency (HRD) predisposes to cancer development, but also provides therapeutic opportunities. Here, we identified an HRD gene signature that robustly predicted HRD status. Unexpectedly, concurrent loss of PTEN in BRCA1-deficient cells might extensively...
ORGANISM(S): Homo sapiens 
2014-01-24 | E-GEOD-54268 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of time-dependent gene expression in MCF-10A cells treated with the HER-2-specific inhibitor CP724,714 for 45 hours
Results of blocking HER-2 kinase activity in MCF-10A cells by treatment with CP724,714 and measuring gene expression as a function of time provides information as to what genes are regulated by HER-2 in these nontransformed breast epithelial cells. MCF-10A cells were treated with the HER-2-specific ...
ORGANISM(S): Homo sapiens 
2011-03-18 | E-GEOD-23138 | biostudies-arrayexpress
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