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ProteomicsCharacterization of the redox proteome in Drosophila melanogaster aging eyes.
During oxidative stress, reactive oxygen species (ROS) can modify and damage cellular proteins. In particular, the thiol groups of cysteine residues can undergo reversible or irreversible oxidative post-translation modifications (PTMs). Identifying the redox-sensitive cysteines on a proteome-wide sc...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2023-04-27 | PXD036110 | Pride
Drosophila eye Oxidative post-translation modifications Redox proteome Aging 
TranscriptomicsEmbryonic atrazine exposure elicits neuroendocrine dysfunction in adult male zebrafish (gonad)
The developmental origins of health and adult disease (DOHaD) hypothesis states that exposure to various environmental stressors early in life can elicit changes to the genome and epigenome thereby resulting in an increased susceptibility of a disease state during adulthood. Atrazine, a common herbi...
ORGANISM(S): Danio rerio 
2016-07-01 | E-GEOD-72242 | biostudies-arrayexpress
TranscriptomicsEmbryonic atrazine exposure elicits neuroendocrine dysfunction in adult male zebrafish (brain)
The developmental origins of health and adult disease (DOHaD) hypothesis states that exposure to various environmental stressors early in life can elicit changes to the genome and epigenome thereby resulting in an increased susceptibility of a disease state during adulthood. Atrazine, a common herbi...
ORGANISM(S): Danio rerio 
2016-07-01 | E-GEOD-72243 | biostudies-arrayexpress
ProteomicsCharacterization of the redox proteome of Drosophila melanogaster S2 cells and w1118 fly eyes.
Reactive oxygen species (ROS) serve as intracellular signaling molecules; however, in excess ROS molecules are damaging to biomacromolecules such as DNA, lipids, and proteins. The excess accumulation of ROS leads to oxidative stress, disrupting redox homeostasis in the cell and has been linked with ...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2023-04-27 | PXD034050 | Pride
Drosophila melanogaster schneider s2 cells Drosophila eye Redox proteome Blue light 
TranscriptomicsAn embryonic atrazine exposure results in reproductive dysfunction in adult zebrafish and morphological alterations in their offspring
The herbicide atrazine, a suspected endocrine disrupting chemical (EDC), frequently contaminates potable water supplies. Studies suggest alterations in the neuroendocrine system along the hypothalamus-pituitary-gonadal axis; however, most studies address either developmental, pubertal, or adulthood ...
ORGANISM(S): Danio rerio 
2016-03-02 | E-GEOD-73740 | biostudies-arrayexpress
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