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MetabolomicsA conserved metabolic signature associated with response to fast-acting antimalarial agents

Characterizing the mode of action of antimalarial compounds that emerge from high-throughput phenotypic screens is central to understanding how parasite resistance to these drugs can emerge. Here, we have employed untargeted metabolomics to inform on the mechanism of action of antimalarial leads ...

2023-09-27 | MTBLS6580 | MetaboLights
GenomicsFactors influencing in vivo deposition of histone variants H3.1 and H3.3
Establishment of a proper chromatin landscape is central to genome function. Here, we explain H3 variant distribution by specific targeting and dynamics of deposition involving the CAF-1 and HIRA histone chaperones. Impairing replicative H3.1 incorporation via CAF-1 enables an alternative H3.3 depos...
ORGANISM(S): Homo sapiens 
2011-12-16 | E-GEOD-31794 | biostudies-arrayexpress
ProteomicsGraft versus host disease treatment with mesenchymal stem cells
graft versus host disease organoids were co-cultured with mesenchymal stem cells
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD034822 | Pride
Msc Proteomics Mass spectrometry Gvhd 
GenomicsCandida albicans induces monocyte training via epigenetic programming through a dectin 1-dependent pathway
Non-specific protective effects against reinfection have been described following infection with Candida albicans. Here we show that mice defective in functional T and B lymphocytes were protected against reinfection with C. albicans in a monocyte-dependent manner. C. albicans and beta glucans induc...
ORGANISM(S): Homo sapiens 
2012-12-21 | E-GEOD-34260 | biostudies-arrayexpress
UnknownGalaxy mothur Toolset (GmT): a user-friendly application for 16S rRNA gene sequencing analysis using mothur.
Not available
S-EPMC6377400 | biostudies-literature
UnknownCancerous breast lesions on dynamic contrast-enhanced MR images: computerized characterization for image-based prognostic markers.
Not available
S-EPMC2826695 | biostudies-literature
UnknownDe-escalation strategies for non-pharmaceutical interventions following infectious disease outbreaks: a rapid review and a proposed dynamic de-escalation framework.
Not available
S-EPMC8444163 | biostudies-literature
UnknownLandscape of Baseline and Acquired Genomic Alterations in Circulating Tumor DNA with Abemaciclib Alone or with Endocrine Therapy in Advanced Breast Cancer.
Not available
S-EPMC11094424 | biostudies-literature
UnknownSafety and efficacy of a cardiovascular polypill in people at high and very high risk without a previous cardiovascular event: the international VULCANO randomised clinical trial.
Not available
S-EPMC9773517 | biostudies-literature
TranscriptomicsGene expression changes induced by overexpression of IDH1mut in the sorted mouse bone marrow cells
Mutations in the enzymes IDH1 and IDH2 have been identified in a wide variety of tumors like glioma, chondrosarcoma, thyroid cancer, lymphoma, melanoma, and in acute myeloid leukemia. Mutated IDH1/2 produces the metabolite 2-hydroxyglutarate (2HG), which interferes with epigenetic regulation of gene...
ORGANISM(S): Mus musculus 
2013-11-05 | E-GEOD-45019 | biostudies-arrayexpress
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