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To investigate the influence of transcription factor knockouts in cell fate decision-making, we performed a CROP-seq screen of 20 transcription factors in brain organoids.
ORGANISM(S): Homo sapiens 
To study developmental trajectories in brain organoids, we conducted scRNA-seq and scATAC-seq in parallel on a dense timecourse of early development.
ORGANISM(S): Homo sapiens 
To study the effect of GLI3 knockout in brain organoids, we collected scRNA-seq data from 45 day old brain organoids with GLI3 KO
ORGANISM(S): Homo sapiens 
To better detect CROP-seq mRNAs in our CROP-seq experiment, we performed amplicon sequencing on the 10X single-cell cDNA libraries
ORGANISM(S): Homo sapiens 
To study developmental trajectories in brain organoids, we conducted scRNA-seq and scATAC-seq in parallel on a dense timecourse of early development.
ORGANISM(S): Homo sapiens 
To investigate GLI3 TF targets during organoid fate decisions, we performed Cut&Tag of GLI3 binding
ORGANISM(S): Homo sapiens 
To investigate how SHH treatment influences patterning of early brain organoids, we performed multiome sequencing of brain organoids during early development
ORGANISM(S): Homo sapiens 
To study the effect of GLI3 knockout on early brain organoid development, we collected single-cell multiome data from 18 day old brain organoids
ORGANISM(S): Homo sapiens 
To investigate the heterogeneity during the neuroepithelial stage of organoid development, we performed a multiome experiment on day 15-18 old brain organoids
ORGANISM(S): Homo sapiens 
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