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MetabolomicsMetabolic Drug Response Phenotyping in Colorectal Cancer Organoids by LC-QTOF-MS
As metabolic rewiring is crucial for cancer cell proliferation, metabolic phenotyping of patient-derived organoids is desirable to identify drug-induced changes and trace metabolic vulnerabilities of tumor subtypes. We established a novel protocol for metabolomic and lipidomic profiling of colorecta...
2021-10-12 | MTBLS2130 | MetaboLights
MetabolomicsFirst-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure

Diminished hepatocyte regeneration is a key feature of acute and chronic liver diseases and after extended liver resections, resulting in the inability to maintain or restore a sufficient functional liver mass. Therapies to restore hepatocyte regeneration are lacking, making liver transplantation...

2024-09-23 | MTBLS9434 | MetaboLights
TranscriptomicsMiRNA expression profiling or ERCC1 deficient and control mouse lineage negative bone marrow cells
MiRNA expression differences induced by ERCC1 deficiency.
ORGANISM(S): Mus musculus 
2015-04-09 | E-MTAB-3298 | biostudies-arrayexpress
TranscriptomicsMiRNA expression profiling or ERCC1 deficient and control mouse lineage negative, ScaI positive, Kit positive (LSK) bone marrow cells
MiRNA expression differences induced by ERCC1 deficiency.
ORGANISM(S): Mus musculus 
2015-04-09 | E-MTAB-3310 | biostudies-arrayexpress
TranscriptomicsGene expression profiling or ERCC1 deficient and control mouse lineage negative bone marrow cells
Transcriptome differences induced by ERCC1 deficiency.
ORGANISM(S): Mus musculus 
2015-04-09 | E-MTAB-3297 | biostudies-arrayexpress
TranscriptomicsIndices of Tolerance (IOT): Cross-platform biomarkers that identify kidney transplant tolerance
Being able to identify patients in whom immunological tolerance has been established or is developing would allow an individually tailored approach to post-transplant management of kidney allograft recipients. Ex vivo immunological monitoring was performed on samples from five groups of European ren...
ORGANISM(S): Homo sapiens 
2010-05-25 | E-GEOD-14655 | biostudies-arrayexpress
Unknown561. Safety of Remdesivir vs Standard Care in Patients with Moderate Covid-19
Not available
S-EPMC7777368 | biostudies-literature
TranscriptomicsInterleukin-10-anergized T-cell infusion provides immune reconstitution without severe graft-versus-host disease after haploidentical hematopoietic stem cell transplantation
Regulatory T cells restore tolerance in preclinical models of immune-mediated diseases and are therefore a promising alternative to conventional immune-suppression for preventing graft-versus-host disease (GvHD) in patients receiving allogeneic hematopoietic stem cell transplantation (HSCT). Adaptiv...
ORGANISM(S): Homo sapiens 
2015-12-14 | E-GEOD-21885 | biostudies-arrayexpress
UnknownImmunogenicity and safety of a booster dose of the hepatitis B vaccine HepB-CpG (HEPLISAV-B®) compared with HepB-Eng (Engerix-B®) and HepB-AS04 (Fendrix®) in adults receiving hemodialysis who previously received hepatitis B vaccination and are not seroprotected: Results of a randomized, multicenter phase 3 study.
Not available
S-EPMC9746491 | biostudies-literature
UnknownIncidence of cancer and overall risk of mortality in individuals treated with raltegravir-based and non-raltegravir-based combination antiretroviral therapy regimens.
Not available
S-EPMC5813233 | biostudies-literature
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