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TranscriptomicsImatinib targeting of KIT-mutant oncoprotein in melanoma
Metastatic melanoma is an aggressive treatment-refractory malignancy. Recently, c-Kit mutations were discovered in certain mucosal melanomas. A clinical trial was initiated with the c-Kit inhibitor imatinib mesylate. The first treated patient experienced dramatic clinical improvement within days, f...
ORGANISM(S): Homo sapiens 
2008-12-23 | E-GEOD-8164 | biostudies-arrayexpress
TranscriptomicsJanus-Like Opposing Roles of CD47 in Autoimmune Brain Inflammation in Human and Mice
Gene transcripts and proteins expressed during disease pathogenesis identify targets for therapy. We performed microarray analysis of histologically characterized multiple sclerosis (MS) brain lesions in comparison with control brain samples to identify differentially expressed molecules. We identif...
ORGANISM(S): Homo sapiens 
2012-06-23 | E-GEOD-38010 | biostudies-arrayexpress
GenomicsSingle-cell heterogeneity in interferon induction potential is heritable and governed by variation in cell state I
Single-cell heterogeneity in interferon induction potential is heritable and governed by variation in cell state I
PRJNA1378211 | ENA
GenomicsSingle-cell heterogeneity in interferon induction potential is heritable and governed by variation in cell state IV
Single-cell heterogeneity in interferon induction potential is heritable and governed by variation in cell state IV
PRJNA1378215 | ENA
GenomicsSingle-cell heterogeneity in interferon induction potential is heritable and governed by variation in cell state II
Single-cell heterogeneity in interferon induction potential is heritable and governed by variation in cell state II
PRJNA1378209 | ENA
GenomicsSingle-cell heterogeneity in interferon induction potential is heritable and governed by variation in cell state III
Single-cell heterogeneity in interferon induction potential is heritable and governed by variation in cell state III
PRJNA1378218 | ENA
TranscriptomicsExpression data from mouse colon tissue response to T cell transfer at week 0, 2, 4 and 6
Temporal geneome profiling of T cell transfer colitis model T cells critically regulate clinical inflammatory bowel diseases and T cell dependent experimental colitis models have gained prominent favor as useful models to identify potential pathogenic mechanisms. The naïve CD4+CD45Rbhigh cell transf...
ORGANISM(S): Mus musculus 
2013-01-11 | E-GEOD-27302 | biostudies-arrayexpress
TranscriptomicsmiRNA Expression In Maintenance and Differentiation of Human Embryonic Stem Cells
Recent advances in the study of human embryonic stem cells (hESCs) and induced-pluripotent stem cells (iPS) highlight their importance as both model systems for basic research and avenues for therapeutic applications. To gain better insight into these cells, a clearer understanding of their molecul...
ORGANISM(S): Homo sapiens 
2010-09-09 | E-GEOD-14473 | biostudies-arrayexpress
TranscriptomicsUnexpected role of interferon-g in regulating neuronal connectivity and social behavior
We identified an enrichment in IFN-gamma dependent genes in the prefrontal cortex of group housed mice compared to single housed mice. Mice were house either grouped or single for 6 days. Mice were euthanized and brains were removed. The prefrontal cortex was disected and prepared for RNA-seq analys...
ORGANISM(S): Mus musculus 
2016-09-06 | E-GEOD-81783 | biostudies-arrayexpress
TranscriptomicsDifferential Gene Expression in HIV-Infected Individuals Following ART.
A paired analysis of peripheral blood mononuclear cells (PBMCs) isolated before and after antiretroviral therapy (ART) from a robust number of HIV-infected patients (N=36). Results identify a total of 4,157 DEGs following ART in HIV-infected participants and the transition from a period of active vi...
ORGANISM(S): Homo sapiens 
2013-09-10 | E-GEOD-44228 | biostudies-arrayexpress
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