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Extracellular vesicles (EVs) have emerged as key messengers in intercellular communications. However, the precise mechanisms of how recipient cells read EV messages are not clear. In this study, we investigated the roles of EV protein cargo, EV parent cell type, and recipient cell type in EV functio...
ORGANISM(S): Homo sapiens (Human) 
2024-07-03 | PXD050024 | Pride
RL95/2 cells treated with JAr cell derived EV
Transcriptional profiling comparison of human primary villous trophoblast and extra-villous trophoblast (VT and EVT respectively) cells, isolated from the placenta at 8 to 12 weeks gestation, with complimentary transcriptional profiling of choriocarcinoma cell lines JEG-3 and JAR. Based on phenotypi...
ORGANISM(S): Homo sapiens 
This miRNA microarray experiment is part of the same multi-omics study as the RNA-seq and whole-exome sequencing data deposited in the European Nucleotide Archive under accession PRJEB122863. The aim of this study was to identify prognostic molecular signatures for GTC patients derived from compreh...
ORGANISM(S): Homo sapiens 
Type II germ cell tumors (GCTs) are the most common neoplasia in young men of age 14-45 years. It is generally accepted that GCTs arise from a common precursor lesion, called germ cell neoplasia in situ (GCNIS), eventually developing into seminomas or non-seminomas, such as (embryonal carcinomas, EC...
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD031329 | Pride
Transcriptome analysis of HPV transfected human trophoblast cells (JAR)
Genomics
Extracellular vesicles from a GBA overexpressing placental cell line and its downstream effects.
Cell lines of different origin (JAR (choriocarcinoma) and THP1 (monocytes, both untreated and activated by LPS/PMA)) expressing the WD40 domain of ATG16L1 fused to GST were lysed and the resulting supernatants subjected to agarose-GSH immunoprecipitation. Co-precipitating proteins were resolved by P...
ORGANISM(S): Homo sapiens (Human) 
2019-03-21 | PXD013180 | Pride
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