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TranscriptomicsTranscription profiling of mouse hypomorphic for ATG16L1 (implicated in Crohns disease) protein expression reveals a key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells
Susceptibility to Crohn's disease, a complex inflammatory disease involving the small intestine, is controlled by over 30 loci. One Crohn's disease risk allele is in ATG16L1, a gene homologous to the essential yeast autophagy gene ATG16 (ref. 2). It is not known how ATG16L1 or autophagy contributes ...
ORGANISM(S): Mus musculus 
2008-11-15 | E-GEOD-13512 | biostudies-arrayexpress
ProteomicsEndothelial PKA targets ATG16L1 to regulate angiogenesis by limiting autophagy
The cAMP-dependent protein kinase A (PKA) regulates a plethora of cellular functions in health and disease. During angiogenesis, PKA activity in endothelial cells controls the transition from sprouting to vessel maturation and limits tip cell formation independently of Notch signaling. The molecular...
ORGANISM(S): Homo sapiens (Human) 
2019-10-04 | PXD012975 | Pride
Autophagy Pka Atg16l1 
GenomicsRole of Atg16L1 in skin biology
Role of Atg16L1 in skin biology
PRJNA906019 | ENA
TranscriptomicsTranscriptional profile in the colon in response to C. rodentium infection.
The identification of Atg16L1 as a susceptibility gene has implicated antibacterial autophagy in the pathogenesis of Crohn's disease, a major type of inflammatory bowel disease (IBD). However, the role of Atg16L1 during extracellular bacterial infections of the intestine has not been sufficiently ex...
ORGANISM(S): Mus musculus 
2013-11-27 | E-GEOD-49109 | biostudies-arrayexpress
ProteomicsIdentification of the protein network associated with EGFP::ATG16L1 and ARHGAP15::MYC
These datasets contain mass spectrometry-based proteomics results from affinity-purification/pulldown assays designed to identify proteins associated with the autophagy regulator EGFP::ATG16L1 and the RAC1-specific GTPase-activating protein ARHGAP15::MYC. Experiments were performed using mouse embry...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2026-06-18 | PXD077984 | Pride
Atg16l1  arhgap15  rac1  autophagy  centrosomes  mouse embryonic fibroblasts  pulldown  mass spectrometry 
GenomicsThe role of ATG16L1 in the intestinal epithelium
The role of ATG16L1 in the intestinal epithelium
PRJNA591208 | ENA
ProteomicsIdentification of proteins able to interact with the WD40 domain of ATG16L1
Cell lines of different origin (JAR (choriocarcinoma) and THP1 (monocytes, both untreated and activated by LPS/PMA)) expressing the WD40 domain of ATG16L1 fused to GST were lysed and the resulting supernatants subjected to agarose-GSH immunoprecipitation. Co-precipitating proteins were resolved by P...
ORGANISM(S): Homo sapiens (Human) 
2019-03-21 | PXD013180 | Pride
Human Autophagy Cell line Atg16l1 
ProteomicsInteractome of ATG16L1 in context of nutrient deprivation
Interactome of ATG16L1 was determined in the context of nutrient deprivation.
ORGANISM(S): Mus musculus (Mouse) 
2026-07-24 | PXD071362 | Pride
Autophagy Atg16l1 
ProteomicsThe V-ATPase/ATG16L1 axis is controlled by the V1H subunit
Defects in organellar acidification indicate compromised or infected compartments. Recruitment of the autophagy-related ATG16L1 complex to pathologically de-acidified compartments targets ubiquitin-like ATG8 molecules to perturbed membranes. How this process is coupled to pH gradient disruption is u...
ORGANISM(S): Homo sapiens (Human) 
2025-01-30 | PXD052945 | Pride
Human Lysosome V-atpase Ph gradient 
TranscriptomicsRole of Atg16L1 in skin biology
In order to unravel the functional role of autophagy in skin homeostasis, we performed single-cell RNA-sequencing on total skin of 10-weeks-old male mice lacking ATG16L1 selectively in keratinocytes. Keratinocyte-specific ATG16L1 knock-out (KO) mice do not show an overt skin phenotype. By performing...
ORGANISM(S): Mus musculus 
2023-07-13 | GSE218854 | GEO
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