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TranscriptomicsHeLa cells treated with V-ATPase inhibitors or with desoxyferramine compared to HeLa in DMSO or medium with low LDL
Expression data from HeLa cells treated with V-ATPase inhibitors or with desoxyferramine compared to HeLa treated with DMSO or medium with low LDL To determine which genes respond first to low concentrations of V-ATPase inhibition, we treated HeLa cells with two different V-ATPase inhibitors, bafil...
ORGANISM(S): Homo sapiens 
2010-07-22 | E-GEOD-16870 | biostudies-arrayexpress
ProteomicsStructure and Topography of the Synaptic V-ATPase–Synaptophysin Complex
Synaptic vesicles are organelles with a precisely defined protein and lipid composition, yet the molecular mechanisms for the biogenesis of synaptic vesicles are mainly unknown. Here, we discovered a well-defined interface between the synaptic vesicle V-ATPase and synaptophysin by in situ cryo-elect...
ORGANISM(S): Mus Musculus 
PXD052814 |
GenomicsV-ATPase-dependent induction of selective autophagy
V-ATPase-dependent induction of selective autophagy
PRJNA1231112 | ENA
ProteomicsYeast TLDc domain-containing proteins control assembly and subcellular localization of the V-ATPase
Yeast vacuoles, equivalent to lysosomes in other eukaryotes, are important acidic degradative organelles as well as storage compartments and signaling hubs. To perform these functions, they rely on important protein complexes, including the V-ATPase, responsible for organelle acidification. In this ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-03-11 | PXD046792 | Pride
Oxr1 Lysosome V-atpase Vacuole Tldc Rtc5 
GenomicsV-ATPase-Driven Lysosomal Activation Orchestrates MEK2-Induced Endothelial Reprogramming
V-ATPase-Driven Lysosomal Activation Orchestrates MEK2-Induced Endothelial Reprogramming
PRJNA1498002 | ENA
ProteomicsThe V-ATPase/ATG16L1 axis is controlled by the V1H subunit
Defects in organellar acidification indicate compromised or infected compartments. Recruitment of the autophagy-related ATG16L1 complex to pathologically de-acidified compartments targets ubiquitin-like ATG8 molecules to perturbed membranes. How this process is coupled to pH gradient disruption is u...
ORGANISM(S): Homo sapiens (Human) 
2025-01-30 | PXD052945 | Pride
Human Lysosome V-atpase Ph gradient 
ProteomicsA Simple Human Embryo Model Reveals V-ATPase Requirement in Mammalian Blastocyst Cavitation
Human naïve pluripotent stem cells (nPSCs) can differentiate into trophectoderm (TE) and self-organize into embryo-like structures known as blastoids, typically requiring complex cocktails of signaling factors. Here, we demonstrate that dimethyl sulfoxide (DMSO) alone robustly induces TE differentia...
ORGANISM(S): Homo sapiens (Human) 
2026-03-12 | PXD069054 | Pride
Blastoids  trophectoderm differentiation  dimethyl sulfoxide  v-atpase  lysosomal acidification 
GenomicsA reversible broad-spectrum antiviral targets the human V-ATPase VO domain
A reversible broad-spectrum antiviral targets the human V-ATPase VO domain
PRJNA1381702 | ENA
ProteomicsLithocholic acid targets TULP3-Sirtuins to deacetylate v-ATPase and activate AMPK
Lithocholic acid (LCA), accumulated in mammals during calorie restriction (CR), can activate AMP-activated protein kinase (AMPK) and slow down ageing1. However, how LCA is signalled to activate AMPK and elicit the biological effects is unclear. Here, we show that LCA can enhance the activity of sirt...
ORGANISM(S): Homo Sapiens Mus Musculus 
PXD056134 |
TranscriptomicsV-ATPase-dependent induction of selective autophagy
The general consensus is that the vacuolar-type H+-translocating ATPase (V-ATPase) is critical for macroautophagy/autophagy. However, there is a fundamental conundrum because follicular lymphoma-associated mutations in the V-ATPase result in lysosomal/vacuolar deacidification but elevated autophagy ...
ORGANISM(S): Saccharomyces cerevisiae 
2025-03-11 | GSE290977 | GEO
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