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ProteomicsYeast TLDc domain-containing proteins control assembly and subcellular localization of the V-ATPase
Yeast vacuoles, equivalent to lysosomes in other eukaryotes, are important acidic degradative organelles as well as storage compartments and signaling hubs. To perform these functions, they rely on important protein complexes, including the V-ATPase, responsible for organelle acidification. In this ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-03-11 | PXD046792 | Pride
Oxr1 Lysosome V-atpase Vacuole Tldc Rtc5 
UnknownInteraction of yeast V-ATPase with TLDc protein Rtc5p.
Not available
S-EPMC12139955 | biostudies-literature
UnknownTLDc Domain-Containing Genes in Autism Spectrum Disorder: New Players in the Oxidative Stress Response.
Not available
S-EPMC10647648 | biostudies-literature
UnknownThe evolutionary conserved TLDc domain defines a new class of (H+)V-ATPase interacting proteins.
Not available
S-EPMC8608904 | biostudies-literature
UnknownCryoEM of endogenous mammalian V-ATPase interacting with the TLDc protein mEAK-7.
Not available
S-EPMC9263379 | biostudies-literature
UnknownYeast TLDc domain proteins regulate assembly state and subcellular localization of the V-ATPase.
Not available
S-EPMC11066047 | biostudies-literature
UnknownThe Evolutionarily Conserved Tre2/Bub2/Cdc16 (TBC), Lysin Motif (LysM), Domain Catalytic (TLDc) Domain Is Neuroprotective against Oxidative Stress.
Not available
S-EPMC4742741 | biostudies-literature
UnknownInteraction between the TBC1D24 TLDc domain and the KIBRA C2 domain is disrupted by two epilepsy-associated TBC1D24 missense variants.
Not available
S-EPMC11465063 | biostudies-literature
UnknownYeast TLDc domain proteins regulate assembly state and subcellular localization of the V-ATPase
Not available
S-SCDT-10_1038-S44318-024-00097-2 | biostudies-other
TranscriptomicsA loss-of-function mutation in human Oxidation Resistance 1 disrupts the spatial-temporal regulation of histone arginine methylation in neurodevelopment
We report a loss-of-function mutation in the TLDc domain of human Oxidation Resistance 1 (OXR1) gene, resulting in early-onset epilepsy, developmental delay, cognitive disabilities, and cerebellar atrophy. Patient lymphoblasts show impaired cell survival, proliferation, and hypersensitivity to oxida...
ORGANISM(S): Homo sapiens 
2023-04-06 | GSE206614 | GEO
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