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Proteomics6-Shogaol Inhibits Oxidative Stress-induced Rat Vascular Smooth Muscle Cell Apoptosis by Regulating OXR1-p53 axis
Apoptosis of vascular smooth muscle cells (VSMCs) is closely related to the pathogenesis of cardiovascular disease, and oxidative stress is an important cause for VSMCs death. Inhibiting VSMCs apoptosis is an effective preventive strategy in slowing down the development of cardiovascular disease, es...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-02-22 | PXD015127 | Pride
Lc-msms Rat Vascular smooth muscle cell 6-shogaol 
GenomicsOxr1-mediated effect on osteoclast differentiation
Knockdown of Oxr1 via siRNA impaired osteoclastogenesis and resorptive function
PRJEB98609 | ENA
UnknownThe antioxidant protein Oxr1 influences aspects of mitochondrial morphology.
Not available
S-EPMC4891067 | biostudies-literature
UnknownOxr1 is essential for protection against oxidative stress-induced neurodegeneration.
Not available
S-EPMC3197693 | biostudies-literature
UnknownOXR1 maintains the retromer to delay brain aging under dietary restriction.
Not available
S-EPMC10784588 | biostudies-literature
UnknownOxr1 improves pathogenic cellular features of ALS-associated FUS and TDP-43 mutations.
Not available
S-EPMC4498158 | biostudies-literature
GenomicsLarge-scale bidirectional arrayed CRISPR screens identify OXR1 and EMC4 as modifiers of α-synuclein aggregation
Large-scale bidirectional arrayed CRISPR screens identify OXR1 and EMC4 as modifiers of α-synuclein aggregation
PRJNA1255183 | ENA
UnknownThe Anopheles gambiae oxidation resistance 1 (OXR1) gene regulates expression of enzymes that detoxify reactive oxygen species.
Not available
S-EPMC2887368 | biostudies-literature
UnknownTranscriptome analysis of human OXR1 depleted cells reveals its role in regulating the p53 signaling pathway.
Not available
S-EPMC4663793 | biostudies-literature
UnknownA novel recessive mutation in OXR1 is identified in patient with hearing loss recapitulated by the knockdown zebrafish.
Not available
S-EPMC10365843 | biostudies-literature
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