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GenomicsJarid1b targets genes regulating development and is involved in neural differentiation [ChIP-seq]
We analyzed the genome-wide binding profile of Jarid1b in mouse ESCs. We find that Jarid1b localizes mainly to transcription start sites, of which more than 50% are also bound by Polycomb proteins and are enriched for genes encoding developmental regulators. Furthermore, we generated genome-wide map...
ORGANISM(S): Mus musculus 
2011-10-26 | E-GEOD-31966 | biostudies-arrayexpress
GenomicsJarid1b targets genes regulating development and is involved in neural differentiation
This SuperSeries is composed of the following subset Series: GSE31966: Jarid1b targets genes regulating development and is involved in neural differentiation [ChIP-seq] GSE31967: Jarid1b targets genes regulating development and is involved in neural differentiation [expression array] Refer to indivi...
ORGANISM(S): Mus musculus 
2011-10-26 | E-GEOD-31968 | biostudies-arrayexpress
TranscriptomicsJarid1b targets genes regulating development and is involved in neural differentiation [expression array]
The H3K4me2/3 histone demethylase Jarid1b (Kdm5b/Plu1) is dispensable for embryonic stem cell (ESC) self-renewal, but essential for ESC differentiation along the neural lineage. During neural differentiation, Jarid1b depleted ESCs fail to efficiently silence lineage-inappropriate genes, specifically...
ORGANISM(S): Mus musculus 
2011-10-26 | E-GEOD-31967 | biostudies-arrayexpress
TranscriptomicsH3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescence (expression)
Cellular senescence is a tumor-suppressive program that involves chromatin reorganization and specific changes in gene expression that trigger an irreversible cell-cycle arrest. We have examined the effect of suppressing the histone demethylases Jarid1a and Jarid1b on the senescence-associated gene ...
ORGANISM(S): Homo sapiens 
2013-01-31 | E-GEOD-43920 | biostudies-arrayexpress
GenomicsThe histone demethylase Jarid1b ensures faithful mouse development by protecting developmental genes from aberrant H3K4me3 [ChIP-Seq]
Embryonic development is tightly regulated by transcription factors and chromatin-associated proteins. H3K4me3 is associated with active transcription and H3K27me3 with gene repression, while the combination of both keeps genes required for development in a plastic state. Here we show that deletion ...
ORGANISM(S): Mus musculus 
2013-04-26 | E-GEOD-41172 | biostudies-arrayexpress
TranscriptomicsThe histone demethylase Jarid1b ensures faithful mouse development by protecting developmental genes from aberrant H3K4me3 [Affymetrix]
Embryonic development is tightly regulated by transcription factors and chromatin-associated proteins. H3K4me3 is associated with active transcription and H3K27me3 with gene repression, while the combination of both keeps genes required for development in a plastic state. Here we show that deletion ...
ORGANISM(S): Mus musculus 
2013-04-26 | E-GEOD-41171 | biostudies-arrayexpress
GenomicsGenome-wide location analysis in breast cancer cell-lines
Recurrent mutations in histone modifying enzymes in multiple cancer types imply key roles in tumorigenesis. However, the functional relevance of these mutations remains unknown. Here we show that the JARID1B histone H3 lysine 4 demethylase is frequently amplified and overexpressed in luminal breast ...
ORGANISM(S): Homo sapiens 
2014-06-17 | E-GEOD-46055 | biostudies-arrayexpress
GenomicsH3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescence
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-01-31 | E-GEOD-43922 | biostudies-arrayexpress
TranscriptomicsHistone Demethylase JARID1B Controls Mammary Gland Development by Regulating Key Developmental Genes
The jmjC-domain containing H3K4 histone demethylase JARID1B/KDM5B/PLU1 is over-expressed in human breast cancer and is a potential target for breast cancer treatment. To investigate the in vivo function of JARID1B, we developed a new strain of Jarid1b knockout mice and characterized the phenotypes i...
ORGANISM(S): Mus musculus 
2014-05-19 | E-GEOD-50479 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of breast cancer cell-lines
Recurrent mutations in histone modifying enzymes in multiple cancer types imply key roles in tumorigenesis. However, the functional relevance of these mutations remains unknown. Here we show that the JARID1B histone H3 lysine 4 demethylase is frequently amplified and overexpressed in luminal breast ...
ORGANISM(S): Homo sapiens 
2014-06-17 | E-GEOD-45732 | biostudies-arrayexpress
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