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Proteomicsozone-derived oxisterols impair lung macrophage phagocytosis via adduction of phagocytosis receptors
Inhalation of the amibient air polution ozone causes lung inflammation and can suppress host defense mechanisms, including impairing macrophage phagocytosis. Ozone reacts with cholesterol in the lung to form oxysterols, like secosterol A and secosterol B, which can form covalent adducts on cellular ...
ORGANISM(S): Homo sapiens (Human) 
2020-07-18 | PXD019317 | Pride
Lung macrophage Bronchoalveolar lavage Click Secosterol a/b Ozone Human Cd206 
TranscriptomicsOzone Exposure Alters MicroRNA Expression Profiles in Humans
We set out to test the hypothesis that ozone inhalation exposure significantly alters miRNA expression profiles within the airway of humans. Adult human volunteers were exposed to 0.4 ppm ozone for two hours. Induced sputum samples were collected from each subject 48 hours pre-exposure and 6 hours p...
ORGANISM(S): Homo sapiens 
2014-07-01 | E-GEOD-47977 | biostudies-arrayexpress
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