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UnknownStructural Properties of NdTiO2+xN1-x and Its Application as Photoanode.
Mixed-anion inorganic compounds offer diverse functionalities as a function of the different physicochemical characteristics of the secondary anion. The quaternary metal oxynitrides, which originate from substituting oxygen anions (O2-) in a parent oxide by nitrogen (N3-), are ...
S-EPMC7884013 | biostudies-literature
TranscriptomicsTranscription profiling of mouse skeletal muscle to detect genes that regulate motor axon growth and differentiation
These experiments are designed to discover genes that are expressed selectively by synaptic nuclei in skeletal muscle with the particular goal of identifying genes that regulate motor axon growth and differentiation. We plan to isolate RNA from the dissected synaptic region of skeletal muscle and fr...
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-2873 | biostudies-arrayexpress
UnknownGrand challenges in entomology: Priorities for action in the coming decades.
Entomology is key to understanding terrestrial and freshwater ecosystems at a time of unprecedented anthropogenic environmental change and offers substantial untapped potential to benefit humanity in a variety of ways, from improving agricultural practices to managing vector-borne diseases and inspi...
S-EPMC10947029 | biostudies-literature
UnknownBRCA1 secondary splice-site mutations drive exon-skipping and PARP inhibitor resistance.
PARP inhibitor (PARPi) therapy has transformed outcomes for patients with homologous recombination DNA repair (HRR) deficient ovarian cancers, for example those with BRCA1 or BRCA2 gene defects. Unfortunately, PARPi resistance is common. Multiple resistance mechanisms have been described, including ...
S-EPMC11299415 | biostudies-literature
UnknownEpigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer.
HNF1B is overexpressed in clear cell epithelial ovarian cancer, and we observed epigenetic silencing in serous epithelial ovarian cancer, leading us to hypothesize that variation in this gene differentially associates with epithelial ovarian cancer risk according to histological subtype. Here we com...
S-EPMC3848248 | biostudies-literature
UnknownDeregulation of MYCN, LIN28B and LET7 in a molecular subtype of aggressive high-grade serous ovarian cancers.
Molecular subtypes of serous ovarian cancer have been recently described. Using data from independent datasets including over 900 primary tumour samples, we show that deregulation of the Let-7 pathway is specifically associated with the C5 molecular subtype of serous ovarian cancer. DNA copy number ...
S-EPMC3076323 | biostudies-literature
UnknownIdentification and molecular characterization of a new ovarian cancer susceptibility locus at 17q21.31.
Epithelial ovarian cancer (EOC) has a heritable component that remains to be fully characterized. Most identified common susceptibility variants lie in non-protein-coding sequences. We hypothesized that variants in the 3' untranslated region at putative microRNA (miRNA)-binding sites represent funct...
S-EPMC3709460 | biostudies-literature
UnknownFine-mapping of the HNF1B multicancer locus identifies candidate variants that mediate endometrial cancer risk.
Common variants in the hepatocyte nuclear factor 1 homeobox B (HNF1B) gene are associated with the risk of Type II diabetes and multiple cancers. Evidence to date indicates that cancer risk may be mediated via genetic or epigenetic effects on HNF1B gene expression. We previously found single-nucleot...
S-EPMC4321445 | biostudies-literature
UnknownSmall-scale mutations are infrequent as mechanisms of resistance in post-PARP inhibitor tumour samples in high grade serous ovarian cancer.
While the introduction of poly-(ADP)-ribose polymerase (PARP) inhibitors in homologous recombination DNA repair (HR) deficient high grade serous ovarian, fallopian tube and primary peritoneal cancers (HGSC) has improved patient survival, resistance to PARP inhibitors frequently occurs. Preclinical a...
S-EPMC10711013 | biostudies-literature
UnknownPrognostic gene expression signature for high-grade serous ovarian cancer.

Background

Median overall survival (OS) for women with high-grade serous ovarian cancer (HGSOC) is ∼4 years, yet survival varies widely between patients. There are no well-established, gene expression signatures associated with prognosis. The aim of this study was to develop a robust prognos...
S-EPMC7484370 | biostudies-literature
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