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ProteomicsIn vivo PDX CRISPR/Cas9 screens reveal mutual therapeutic targets to overcome heterogeneous acquired chemo-resistance
Resistance towards cancer treatment represents a major clinical obstacle, preventing cure of cancer patients. To gain mechanistic insights, we developed a model for acquired resistance to chemotherapy by treating mice carrying patient derived xenografts (PDX) of acute lymphoblastic leukemia with wid...
ORGANISM(S): Homo sapiens (Human) 
2023-01-02 | PXD036517 | Pride
Chemoresistance Leukemia Proteome Drug resistance Pdx 
ProteomicsCombined proteomics and CRISPR-Cas9 screens in PDX identify ADAM10 as essential for leukemia in vivo
Acute leukemias represent deadly malignancies which require better treatment. As challenge, treatment is counteracted by a microenvironment protecting dormant leukemia stem cells. To identify responsible surface proteins, we performed deep proteome profiling on minute numbers of dormant patient-deri...
ORGANISM(S): Homo sapiens (Human) 
2023-07-24 | PXD036223 | Pride
Leukemia stem cell Proteome Adam10 Crispr Leukemia Dia pasef 
ProteomicsSuperior Anti-tumor Efficacy of CD4+ CAR-T Cells against Acute Leukemias
While chimeric antigen receptor T-cell (CART) therapy has shown impressive therapeutic efficacy in several hematologic malignancies, primary or secondary treatment failure remains a significant challenge driving investigators to explore opportunities to improve the functionality of CART products. In...
ORGANISM(S): Homo sapiens (Human) 
2026-09-28 | PXD060508 | Pride
Acute leukemia Antitumor activity Car-t therapy Cd4+ t-cells 
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