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Proteomics,MultiomicsCyclin C-CDK3/8/19 kinases play a tumor-suppressive role in vivo
Cyclin C was cloned as a growth-promoting G1 cyclin1,2, and several studies postulated a role for cyclin C in driving cell proliferation3-8 . Moreover, cyclin C, together with its kinase partner, the cyclin-dependent kinase CDK8, is believed to represent an essential component of basal transcrip...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080728 | MassIVE
MetabolomicsFunctional analysis of isoprenoid precursors biosynthesis by quantitative metabolomics and isotopologue profiling

INTRODUCTION: Isoprenoids are amongst the most abundant and diverse biological molecules and are involved in a broad range of biological functions. Functional understanding of their biosynthesis is thus key in many fundamental and applicative fields, including systems biology, me...

2021-04-01 | MTBLS923 | MetaboLights
UnknownA J-shaped relationship between caloric intake and survival in critically ill patients.
Not available
S-EPMC4635112 | biostudies-literature
MetabolomicsIntegrated genomic and metabolomic profiling of ISC1, an emerging Leishmania donovani population in the Indian subcontinent

Leishmania donovani is the responsible agent for visceral leishmaniasis (VL) in the Indian subcontinent (ISC). The disease is lethal without treatment and causes 0.2 to 0.4 million cases each year. Recently, reports of VL in Nepalese hilly districts have increased as well as VL cases cau...

2022-09-15 | MTBLS1606 | MetaboLights
MetabolomicsTranscriptional Shift and Metabolic Adaptations during Leishmania Quiescence Using Stationary Phase and Drug Pressure as Models

Microorganisms can adopt a quiescent physiological condition which acts as a survival strategy under unfavourable conditions. Quiescent cells are characterized by slow or non-proliferation and deep down-regulation of processes related to biosynthesis. Although quiescence has been described mostly...

2022-02-23 | MTBLS4046 | MetaboLights
UnknownImpact of rewarming rate on interleukin-6 levels in patients with shockable cardiac arrest receiving targeted temperature management at 33 °C: the ISOCRATE pilot randomized controlled trial.
Not available
S-EPMC8680374 | biostudies-literature
ModelsLeloup1999_CircadianRhythms_Drosophila
This a model from the article: Limit cycle models for circadian rhythms based on transcriptional regulation in Drosophila and Neurospora. Leloup JC, Gonze D, Goldbeter A. J Biol Rhythms.1999 Dec;14(6):433-48. 10643740, Abstract: We exami...
2024-09-02 | BIOMD0000000298 | BioModels
ModelsLeloup1999_CircadianRhythms_Neurospora
This a model from the article: Limit cycle models for circadian rhythms based on transcriptional regulation in Drosophila and Neurospora. Leloup JC, Gonze D, Goldbeter A. J Biol Rhythms. 1999 Dec;14(6):433-48. 10643740 , ...
2024-09-02 | BIOMD0000000299 | BioModels
MetabolomicsFour layer multi-omics reveals molecular responses to aneuploidy in Leishmania

Aneuploidy causes system-wide disruptions in the stochiometric balances of transcripts, proteins, and metabolites, often resulting in detrimental effects for the organism. The protozoan parasite Leishmania has an unusually high tolerance for aneuploidy, but the molecular and functional consequenc...

2022-09-19 | MTBLS1612 | MetaboLights
TranscriptomicsOdontoblast-like cells and dental pulp fibroblasts stimulated with LTA, poly(I:C) and LPS.
Odontoblasts and fibroblasts are suspected to influence the innate immune response triggered in the dental pulp by micro-organisms that progressively invade the human tooth during the carious process. To determine whether they differ in their responses to oral pathogens, we performed a systematic co...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-9560 | biostudies-arrayexpress
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