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TranscriptomicsExpression RNA-Seq data of matched cases of pre-treatment Fine-needle aspiration (FNA) and the respective post neo-adjuvant treatment operative sample of breast cancer patients.
Neoadjuvant treated patients were selected from the Genomstudy of the University Women`s Clinic Heidelberg (2009-2016). This study includes primary breast cancer cases that were newly diagnosed at the University women's clinic of Heidelberg and had given their informed consent for participating in t...
ORGANISM(S): Homo sapiens 
2017-05-15 | E-MTAB-4632 | biostudies-arrayexpress
MetabolomicsMetabolic memory underlying minimal residual disease in breast cancer

Tumor relapse from treatment-resistant cells (minimal residual disease, MRD) underlies most breast cancer related deaths. Yet, the molecular characteristics defining their malignancy have largely remained elusive. Here we integrated multi-omics data from a tractable organoid system with a metabol...

2021-09-14 | MTBLS1507 | MetaboLights
TranscriptomicsRNA-seq of doxycycline induced tumor and residual mouse primary mammary epithelial cells grown in 3D cell cultures against non-induced controls
This experiment investigates the expression characteristics of residual breast cancer cells. Primary mammary epithelial cells taken from female mice with doxycycline-inducible hMyc- and Neu/Her2-oncogenes were grown in 3D organoid cultures. Upon the addition of doxycycline (200ng/mL) to the medium t...
ORGANISM(S): Mus musculus 
2020-12-31 | E-MTAB-8834 | biostudies-arrayexpress
GenomicsEnzymatic Methyl-seq (EM-seq) of doxycycline induced tumor and residual mouse primary mammary epithelial cells grown in 3D cell cultures against non-induced controls
This experiment investigates the genome wide DNA methylation landscape of residual breast cancer cells. Primary mammary epithelial cells taken from female mice with doxycycline-inducible hMyc- and Neu/Her2-oncogenes were grown in 3D organoid cultures. Upon the addition of doxycycline (200ng/mL) to t...
ORGANISM(S): Mus musculus 
2021-10-03 | E-MTAB-10979 | biostudies-arrayexpress
TranscriptomicsTemporal Transcriptional Profiling in response to cMYC and Her2/NEU Expression and Inactivation in In Vitro Cultured Primary Mammary Epithelial Cells of Adult Virgin Mice
Mammary glands from 8 week old, female, virgin GEMM MMTV-rtTA/TetO-MYC/TetO-Neu mice were dissociated into single cells and seeded into matrigel matrix for in vitro culture. To determine the gene expression changes which occur upon oncogene induction 5 days after seeding doxycycline was added to th...
ORGANISM(S): Mus musculus 
2017-05-22 | E-MTAB-3039 | biostudies-arrayexpress
TranscriptomicsTemporal Transcriptional Profiling in response to cMYC and KrasG12D Expression and Inactivation in In Vitro Cultured Primary Mammary Epithelial Cells of Adult Virgin Mice
Mammary glands from 8 week old, female, virgin GEMM MMTV-rtTA/TetO-MYC/TetO-KrasG12D mice were dissociated into single cells and seeded into matrigel matrix for in vitro culture. To determine the gene expression changes which occur upon oncogene induction 5 days after seeding doxycycline was added ...
ORGANISM(S): Mus musculus 
2017-05-22 | E-MTAB-3038 | biostudies-arrayexpress
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