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TranscriptomicsBET Protein Inhibitor JQ1 Induces Cell Cycle Arrest in Mesenchymal Stem Cells
Efficacy and safety of anticancer drugs are traditionally studied using cancer cell lines and animal models. Recently, a potential anticancer agent, JQ1, an inhibitor of bromodomain and extra terminal (BET) protein, has been shown to promote apoptosis of cancerous cells by arresting them in G1 phase...
ORGANISM(S): Homo sapiens 
2016-02-12 | E-GEOD-70577 | biostudies-arrayexpress
GenomicsGenomewide occupancy of the synovial sarcoma-associated SYT-SSX2 oncoprotein in C2C12 myoblasts
Synovial sarcoma is a rare malignancy that is characterized by the presence of a chromosomal translocation t(X;18). This genetic abnormality results in the fusion of 2 transcriptional co-regulators, SYT and SSX, which have been shown to mediate transcriptional activation and repression, respectivel...
ORGANISM(S): Mus musculus 
2011-09-26 | E-GEOD-26564 | biostudies-arrayexpress
TranscriptomicsGene expression profile of SYT-SSX2-expressing human bone marrow-derived mesenchymal stem cells
Synovial sarcoma is a rare malignancy characterized by the presence of a specific chromosomal translocation t(X;18) that results in the formation of a fusion protein SYT-SSX. Because it is believed that synovial sarcoma arises from mesenchymal stem or progenitor cells, we used human bone marrow-deri...
ORGANISM(S): Homo sapiens 
2011-09-25 | E-GEOD-26563 | biostudies-arrayexpress
TranscriptomicsThe Histone H2B Monoubiquitination Regulatory Pathway is Required for Differentiation of Multipotent Stem Cells
Extensive changes in post-translational histone modifications accompany the rewiring of the transcriptional program during stem cell differentiation. However, the mechanisms controlling the changes in specific chromatin modifications and their function during differentiation remain only poorly under...
ORGANISM(S): Homo sapiens 
2013-01-03 | E-GEOD-38173 | biostudies-arrayexpress
TranscriptomicsReprogramming of mesenchymal stem cells by the synovial sarcoma-associated oncogene SYT-SSX2
Cellular identity is determined by its gene expression programs. The ability of the cell to change its identity and produce cell types outside its lineage is achieved by the activity of transcription controllers capable of reprogramming differentiation gene networks. The synovial sarcoma associated ...
ORGANISM(S): Homo sapiens 
2011-09-25 | E-GEOD-26565 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of honey bee queens Apis mellifera L. to investigate the differential effects of insemination volume and substance on reproductive changes
Mating causes dramatic changes in female insects at the behavioral, physiological, and molecular levels. The factors driving these changes (e.g., seminal proteins, seminal volume) and the molecular pathways by which these factors are operating have been characterized only in a handful of insect spe...
ORGANISM(S): Apis mellifera 
2013-05-21 | E-MEXP-3681 | biostudies-arrayexpress
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