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ProteomicsChronic lymphocytic leukaemia cells exhibit functional heterogeneity in the unfolded protein response: a proteomic study
Genomic, epigenomic, and transcriptomic studies have provided only a partial explanation of disease heterogeneity in chronic lymphocytic leukaemia (CLL). Since mRNA and protein expression do not always correlate, CLL heterogeneity was investigated using global cellular proteomics. Sequential Window...
ORGANISM(S): Homo sapiens (Human) 
2025-08-04 | PXD058183 | Pride
Chronic lymphocytic leukaemia Disease heterogeneity Response to therapy Unfolded protein response 
ProteomicsExosomal transport of hepatocyte-derived drug-modified proteins to the immune system
Idiosyncratic drug-induced liver injury (DILI) is a rare, often difficult to predict adverse reaction with complex pathomechanisms. However, it is now evident that certain forms of DILI are immune-mediated and may involve the activation of drug-specific T-cells. Exosomes are cell-derived vesicles th...
ORGANISM(S): Homo sapiens (Human) 
2019-05-14 | PXD010760 | Pride
Exosomes Hepatocytes Immune response Drug-induced liver injury 
ProteomicsCLL iTRAQ1 - Total proteome analysis identifies migration defects as a major pathogenetic factor in immunoglobulin heavy chain variable region (IGHV)-unmutated chronic lymphocytic leukemia
The mutational status of the immunoglobulin heavy chain variable region (IGHV) defines two clinically distinct forms of chronic lymphocytic leukemia (CLL) known as mutated (M-CLL) and un-mutated (UM-CLL). To elucidate the molecular mechanisms underlying the adverse clinical outcome associated with U...
ORGANISM(S): Homo sapiens (Human) 
2016-06-27 | PXD001512 | Pride
Human Leukemia Itraq Mutation 
ProteomicsCLL iTRAQ2 - Total proteome analysis identifies migration defects as a major pathogenetic factor in immunoglobulin heavy chain variable region (IGHV)-unmutated chronic lymphocytic leukemia
The mutational status of the immunoglobulin heavy chain variable region (IGHV) defines two clinically distinct forms of chronic lymphocytic leukemia (CLL) known as mutated (M-CLL) and un-mutated (UM-CLL). To elucidate the molecular mechanisms underlying the adverse clinical outcome associated with U...
ORGANISM(S): Homo sapiens (Human) 
2016-06-27 | PXD001515 | Pride
Human Leukemia Itraq Mutation 
ProteomicsCLL iTRAQ3 - Total proteome analysis identifies migration defects as a major pathogenetic factor in immunoglobulin heavy chain variable region (IGHV)-unmutated chronic lymphocytic leukemia
The mutational status of the immunoglobulin heavy chain variable region (IGHV) defines two clinically distinct forms of chronic lymphocytic leukemia (CLL) known as mutated (M-CLL) and un-mutated (UM-CLL). To elucidate the molecular mechanisms underlying the adverse clinical outcome associated with U...
ORGANISM(S): Homo sapiens (Human) 
2016-06-27 | PXD001516 | Pride
Human Leukemia Itraq Mutation 
ProteomicsThe dipeptide prolyl-hydroxyproline promotes cellular homeostasis and lamellipodia-driven motility via active ?1-integrin in adult tendon cells
Collagen-derived hydroxyproline-containing peptides show a variety of biological properties in cells. However, no comprehensive study has yet explored the functional links between Hyp-containing peptides and cellular behavior. Here, we show that the dipeptide prolyl-hydroxyproline (Pro–Hyp) exhibits...
ORGANISM(S): Mus musculus (Mouse) 
2021-05-27 | PXD023176 | Pride
Collagen-derived peptide  proline-hydroxyproline  adult tendon cells  extracellular matrix  scleraxis  cell motility  extracellular signal-regulated kinase 
ProteomicsCollagen-derived prolyl-hydroxyproline dipeptide promotes cellular homeostasis and lamellipodia-driven cell motility through active β1-integrin in adult tendon cells
Collagen-derived hydroxyproline-containing peptides show a variety of biological properties in cells. However, no comprehensive study has yet explored the functional links between Hyp-containing peptides and cellular behavior. Here, we show that the dipeptide prolyl-hydroxyproline (Pro–Hyp) exhibits...
ORGANISM(S): Mus musculus (Mouse) 
2022-09-28 | PXD020374 | Pride
Collagen-derived peptide  proline-hydroxyproline  adult tendon cells  extracellular matrix  scleraxis  cell motility  extracellular signal-regulated kinase 
ProteomicsMultiomic temporal landscape of plasma and synovial fluid derived extracellular vesicles using an experimental model of equine osteoarthritis
Osteoarthritis (OA) is the most common equine joint disease characterised by cartilage degradation and changes to other joint tissues severely effecting welfare and performance leading to early retirement. It results in substantial morbidity and mortality, but our understanding of the pathophysiolog...
ORGANISM(S): Equus caballus (Horse) 
2023-10-24 | PXD041515 | Pride
Proteins Osteoarthritis Extracellular vesicles Plasma Small non-coding rna Synovial fluid 
UnknownGenome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder.
Not available
S-EPMC11396662 | biostudies-literature
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