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GenomicsGenome-wide regulatory analysis reveals T-bet controls Th17 lineage differentiation through direct suppression of IRF4
The complex relationship between Th1 and Th17 cells is incompletely understood. The transcription factor T-bet is best known as the master regulator of Th1 lineage commitment. However, attention is now focused on the repression of alternate T cell subsets mediated by T-bet, particularly the Th17 lin...
ORGANISM(S): Mus musculus 
2013-12-03 | E-GEOD-40623 | biostudies-arrayexpress
TranscriptomicsHuman Immunodeficiency Virus Tat Directly Interacts with a Specific Set of Cellular RNAs
We have used RNA immunoprecipitation to identify the set of mRNAs that HIV-1 Tat interacts with in T-cells. We have also performed measurements of relative RNA abundance to determine if Tat binding is associated with an increase in RNA abundance in Tat-expressing T-cells and during HIV infection of ...
ORGANISM(S): Homo sapiens 
2013-11-05 | E-MEXP-3199 | biostudies-arrayexpress
ProteomicsNascent RNA antagonises the interaction of regulatory proteins with chromatin
Using label-free quantification to identify the changes in the association of proteins with chromatin upon RNA degradation in cells with RNaseA.
ORGANISM(S): Mus musculus (Mouse) 
2021-06-25 | PXD018641 | Pride
Mouse chromatin chromatome lc-msms 
TranscriptomicsChromatin immunoprecipitation of human MLL1 to understand its role in cell type specification
An experiment was performed to understand its role in cell type specification, we have determined the human genomic binding sites of MLL1. MLL1 localizes with Pol II to the 5' end of actively transcribed genes, where histone H3 lysine 4 (H3-K4) trimethylation occurs. The ability of MLL1 to serve as ...
ORGANISM(S): Homo sapiens 
2005-06-03 | E-WMIT-4 | biostudies-arrayexpress
UnknownInhibition of Histone H3K27 Demethylases Inactivates Brachyury (TBXT) and Promotes Chordoma Cell Death.
Not available
S-EPMC7616956 | biostudies-literature
UnknownEpstein-Barr virus transcription factor Zta acts through distal regulatory elements to directly control cellular gene expression.
Not available
S-EPMC4402532 | biostudies-literature
UnknownCTLA-4 expressing innate lymphoid cells modulate mucosal homeostasis in a microbiota dependent manner.
Not available
S-EPMC11535242 | biostudies-literature
UnknownSecond malignancies in the context of lenalidomide treatment: an analysis of 2732 myeloma patients enrolled to the Myeloma XI trial.
Not available
S-EPMC5223149 | biostudies-literature
UnknownMaintenance lenalidomide in newly diagnosed transplant eligible and non-eligible myeloma patients; profiling second primary malignancies in 4358 patients treated in the Myeloma XI Trial.
Not available
S-EPMC10404862 | biostudies-literature
UnknownEfficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 lineages circulating in Brazil.
Not available
S-EPMC8494913 | biostudies-literature
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