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TranscriptomicsThe Hematopoietic System - Myeloid arm
We used microarray to create a normal cell landscape for the myeloid arm of the hematopoietic system. Mononuclear bone marrow cells from heathly donors were enriched for 34+ and hematopoietic stem and progenitor cells were sorted by FACS.
ORGANISM(S): Homo sapiens 
2014-01-01 | E-GEOD-42519 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of normal and cancerous human breast cell lines and tissues to explore HOXA gene expression in context of other homological genes and in context of physical location in genome
Expression profiles of normal and cancerous cell and tissue were used for exploring HOXA genes expression in context of other homological genes (HOXB,HOXC,HOXD) and in context of physical location in genome
ORGANISM(S): Homo sapiens 
2006-11-03 | E-MEXP-882 | biostudies-arrayexpress
TranscriptomicsMethylation profiling of normal and cancerous human breast samples
To assess changes in DNA methylation state associated with breast cancer we analyzed DNA from normal and cancerous breast specimens on CpG islands microarray using methylation-sensitive enzyme McrBC for target preparation. Cy3 was used for McrBC cut sample, Cy5 was used for reference Mock sample.
ORGANISM(S): Homo sapiens 
2006-11-03 | E-MEXP-881 | biostudies-arrayexpress
TranscriptomicsMethylation profiling of normal and cancerous breast cells from human patients and cell lines in a 125 kB region of the HOXA cluster
To evaluate DNA methylation profile associated with breast cancer in 125 kB region of HOXA cluster we analyzed DNA from normal cancerous breast specimens and cell lines. Analysis was performed on the tiling array covering entire HOXA region with 500bp resolution. Immunoprecipitation with anti-methyl...
ORGANISM(S): Homo sapiens 
2006-11-03 | E-MEXP-880 | biostudies-arrayexpress
TranscriptomicsDefining the effect of extracellular matrix on cellular identity
Intestinal epithelial cells from the small intestine were seeded in either Matrigel or purified Type I Collagen in order to define the effect of matrix on cell fate.
ORGANISM(S): Mus musculus 
2017-11-30 | E-MTAB-5247 | biostudies-arrayexpress
TranscriptomicsDefining the molecular properties of the repairing epithelium during DSS induced colitis
In order to understand the molecular changes associated with the establishment of the repairing epithelium following dextran sulfate sodium (DSS) induced injury of the colon we have isolated Epcam+Sca1+ expressing epithelial cells from repairing tissue and Epcam+ homeostatic intestine. Cells isolate...
ORGANISM(S): Mus musculus 
2017-11-30 | E-MTAB-5249 | biostudies-arrayexpress
UnknownA phase II study of retifanlimab (INCMGA00012) in patients with squamous carcinoma of the anal canal who have progressed following platinum-based chemotherapy (POD1UM-202).
Not available
S-EPMC9463376 | biostudies-literature
TranscriptomicsMethylation profiling of human normal and cancer tissues to identify long range epegenetic aberations
Affymetrix Tiling Promoter arrays was used to find differentially methylated region in cancerous and norma tissue to identify long range epegenetic aberation
ORGANISM(S): Homo sapiens 
2008-08-20 | E-MEXP-1481 | biostudies-arrayexpress
TranscriptomicsRNA-seq of murine small intestinal organoids treated with type I PRMT inhibitor MS023 against untreated controls
Murine small intestinal organoids were cultured in the presence or absence of 5µM inhibitor MS023 (PubChem CID 92136227), which targets type I protein arginine methyltransferases Prmt1, Prmt3, Prmt4, Prmt6, Prmt8. Organoids were grown in culture media containing EGF, Noggin and R-spondin (ENR), medi...
ORGANISM(S): Mus musculus 
2020-12-16 | E-MTAB-9291 | biostudies-arrayexpress
TranscriptomicsDifferential regulation of microRNAs in skeletal muscle from monozygotic twins discordant for type 2 diabetes
Analysis of microRNA expression in vastus lateralis muscle biopsies from 11 genetically identical twin pairs discordant for type 2 diabetes. This eliminates the influence of genotype and leads to the identification of microRNAs that are exclusively influenced by environmental (non-genetic) factors. ...
ORGANISM(S): Homo sapiens 
2014-11-19 | E-GEOD-38835 | biostudies-arrayexpress
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