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TranscriptomicsZbtb20-mediated repression of genes in developing CA1 pyramidal neurons
The transcriptional repressor Zbtb20 is essential for specification of hippocampal CA1 pyramidal neurons. Moreover, ectopic expression of Zbtb20 is sufficient to transform subicular and retrosplenial areas of D6/Zbtb20S mice to CA1. We used microarrays to identify genes that are repressed by Zbtb20 ...
ORGANISM(S): Mus musculus 
2014-04-11 | E-GEOD-38837 | biostudies-arrayexpress
TranscriptomicsGenome-wide study of nuclear poly(A) binding protein Nab2p depletion
Polyadenylation of mRNA is a key step in eu- karyotic gene expression. However, despite the ma- jor impact of poly(A) tails on mRNA metabolism, the precise roles of poly(A)-binding proteins (PABPs) in nuclear mRNA biogenesis remain elusive. Here, we demonstrate that rapid nuclear depletion of the S....
ORGANISM(S): Saccharomyces cerevisiae 
2015-08-13 | E-GEOD-65001 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human skeletal muscle of PCOS patients after pioglitazone therapy
Insulin resistance is a common metabolic abnormality in women with PCOS and leads to an elevated risk of type 2 diabetes. Studies have shown that thiazolidinediones (TZD) improve metabolic disturbances in PCOS patients. We hypothesized that the effect of TZD in PCOS is in part mediated by changes in...
ORGANISM(S): Homo sapiens 
2008-11-14 | E-GEOD-8157 | biostudies-arrayexpress
TranscriptomicsAn atlas of active enhancers across human cell types and tissues
Sequencing of 5' ends of RNA molecules from control and exosome-depleted HeLa-S3 cells. CAGE library construction from RNA extracted from control and exosome-depleted cells.
ORGANISM(S): Homo sapiens 
2014-03-26 | E-GEOD-49834 | biostudies-arrayexpress
TranscriptomicsThe human nuclear exosome targeting complex is loaded onto newly synthesized RNA to direct early ribonucleolysis
Individual-nucleotide resolution UV-crosslinking and immunoprecipitation (iCLIP) followed by high-throughput sequencing of RBM7-associated transcripts. Note: these data relate to Figure 1, 2, 3, 4, 5 and 6 in Lubas, Andersen et al., Cell Reports 2014 RBM7-associated transcripts
ORGANISM(S): Homo sapiens 
2014-12-03 | E-GEOD-63791 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human skeletal muscle of women with PCOS reveals reduced expression of mitochondrial oxidative metabolism genes
Recently, abnormalities in mitochondrial oxidative phosphorylation (OXPHOS) have been implicated in the pathogenesis of skeletal muscle insulin resistance in type 2 diabetes. In the present study, we hypothesized that decreased expression of OXPHOS genes could be of similar importance for insulin re...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-6798 | biostudies-arrayexpress
TranscriptomicsHigh-throughput sequencing of PROMPT-enriched samples.
Sequencing of 5' and 3'ends and RNA-seq of PROMPT and mRNA molecules from control and exosome-depleted cells. CAGE, 3'TAG and RNAseq library construction from RNA extracted from control and exosome-depleted cells.
ORGANISM(S): Homo sapiens 
2013-07-03 | E-GEOD-48286 | biostudies-arrayexpress
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