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In Caenorhabditis elegans, the six proteins that make up the REF-1 family are HES homologs that act in both Notch dependent and Notch-independent pathways to regulate embryonic events. To further our understanding of how the REF-1 family works to coordinate post-embryonic cellular events, we perfor...
ORGANISM(S): Caenorhabditis elegans 
We develop a parallel flow projection and transfer learning-based spatial proteomics framework that combines microfluidics and a deep neutral network.
ORGANISM(S): Homo Sapiens Rattus Norvegicus Mus Musculus 
2025-01-15 | PXD045687 |
Our study have shown that PPDPF promoted NF-κB activation through TRIM21-mediated K63-linked ubiquitination of RIPK1 in hepatocytes. Upon TNF-α stimulation, PPDPF enhances TRIM21/RIPK1 interaction and increases TRIM21-mediated K63-linked ubiquitination of RIPK1, which promotes NF-κB activation.To ma...
ORGANISM(S): Homo Sapiens 
2023-02-21 | PXD040301 |
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