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ProteomicsNuclear SIRT3 counteracts human stem cell senescence
Sirtuin 3 (SIRT3) is an NAD+-dependent deacetylase involved in various physiological and pathological processes. However, the role of SIRT3 in regulating human stem cell senescence remains largely unknown. Here, we observed the downregulated expression of SIRT3 in senescent human mesenchymal stem ce...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD023479 | Pride
Sirt3 stem cell aging lad 
ProteomicsPDI-catalyzed oxidative protein folding mediates senescence by induction of ER-derived oxidative stress
Protein homeostasis is linked with aging and aging associated diseases. Oxidative protein folding occurs in the endoplasmic reticulum (ER) and produces H2O2 as a byproduct. The role of oxidative protein folding in human stem cells aging remains unknown. Here, we succeed to knockout protein disulfide...
ORGANISM(S): Homo sapiens (Human) 
2023-06-12 | PXD037244 | Pride
Human mesenchymal stem cells (hmscs)  hydrogen peroxide (h2o2)  oxidative 29 protein folding  protein disulfide isomerase (pdi)  senescence 
Proteomics4E-BP1 counteracts human stem cell senescence via maintaining mitochondrial homeostasis
Although the mTOR-4E-BP1 signaling pathway is implicated in aging and aging-related disorders, the role of 4E-BP1 in regulating human stem cell homeostasis remains largely unknown. Here, we report that the expression of 4E-BP1 decreases along with the senescence of human mesenchymal stem cells (hMSC...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD033301 | Pride
Eif4ebp1 mitochondria oxidative phosphorylation 
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