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MetabolomicsHyocholic acid species as novel biomarkers for metabolic disorders
Hyocholic acid (HCA) is a major bile acid (BA) species in the BA pool of pigs, a species known for its exceptional resistance to spontaneous development of diabetic phenotypes. HCA and its derivatives are also present in human blood and urine. We investigate whether human HCA profiles can predict th...
2021-10-06 | MTBLS2343 | MetaboLights
MetabolomicsDT-109 ameliorates nonalcoholic steatohepatitis in nonhuman primates

Nonalcoholic steatohepatitis (NASH) prevalence is rising with no pharmacotherapy approved. A major hurdle in NASH drug development is the poor translatability of preclinical studies to safe/effective clinical outcomes, and recent failures highlight a need to identify new targetable pathways. Dysr...

2023-04-13 | MTBLS5005 | MetaboLights
MetabolomicsKidney Tissue Targeted Metabolic Profiling of Unilateral Ureteral Obstruction Rats by NMR
Renal interstitial fibrosis is a common pathological process in the progression of kidney disease. A nuclear magnetic resonance (NMR) based metabolomics approach was used to analyze the kidney tissues of renal interstitial fibrosis (RIF) rats, induced by unilateral ureteral obstruction (UUO). The co...
2017-10-09 | MTBLS361 | MetaboLights
ProteomicsProteomic and clinical biomarkers for acute mountain sickness diagnosis, prognosis, protection, and pathogenesis in a longitudinal cohort
We redefined AMS by using the combination of Olink’s antibody-based proximity extension assay and the multiple reaction monitoring mass spectrometry proteome with 106 paired plasma samples of Chinese Han, 22 AMS-related phenotypes, and 65 clinical indexes. We revealed a systematic proteomic and clin...
ORGANISM(S): Homo Sapiens 
2021-10-12 | PXD029063 |
ProteomicsProteomics-based mechanistic investigation of Escherichia coli inactivation by pulsed electric field
mechanistic investigation of Escherichia coli inactivation
ORGANISM(S): Escherichia Coli Vdp 
2019-06-25 | PXD014365 |
ProteomicsProteomics-based mechanistic investigation of Staphylococcus aureus inactivation by pulsed electric field
The Staphylococcus aureus strain was cultured in LB medium at 150 rpm and 37 ℃ to a final optical density (OD) of 1.0 at 600 n m. Subsequently, 1 m L of the culture broth was collected and centrifuged at 8000 rpm, 4 ℃ for 2 min. The cell pellet was re-suspended in 2 m L of ice-cold 0.1% (w/v) bacter...
ORGANISM(S): Staphylococcus Aureus 
2021-06-17 | PXD026761 |
ProteomicsInhibition of a novel CLK1-THRAP3-PPARγ axis improves insulin sensitivity
CLK1 plays a critical role in controlling energy expenditure through the CLK1-Thrap3-PPARγ axis.
ORGANISM(S): Homo Sapiens Mus Musculus 
2021-08-16 | PXD027958 |
ProteomicsModulation of Microbial Bile Acid Metabolism by DT-109 Ameliorates Nonalcoholic Steatohepatitis in Nonhuman Primates
Modulation of Microbial Bile Acid Metabolism by DT-109 Ameliorates Nonalcoholic Steatohepatitis in Nonhuman Primates
ORGANISM(S): Macaca Fascicularis Fascicularis 
2023-02-10 | PXD040009 |
ProteomicsSerum proteomics of individuals with MASLD under resistance starch intervention
Searching for baseline proteins that contribute to the individual response to RS intervention
ORGANISM(S): Homo Sapiens 
2025-09-24 | PXD068798 |
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