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TranscriptomicsC/EBPbeta-2 regulation of gene expression in MCF10A cells
C/EBPbeta-2 results in EMT and ErbB indpendence this project investigated the gene changes in related genes upon C/EBPbeta-2 overexpression in MCF10A cells. We used microarray analysis to detail the global gene expression mediated by C/EBPbeta-2 and identified changes in known EMT genes, however, k...
ORGANISM(S): Homo sapiens 
2010-03-06 | E-GEOD-15065 | biostudies-arrayexpress
TranscriptomicsGene expression data from human metastatic melanoma tumors that may predict response to RAF265
To determine how mutation of BRAF affected the response to RAF265, we utilized a tumor orthotopic implant model of early passage melanoma tumors in nude mice from a series of 17 patients with advanced metastatic Tumor growth was compared between RAF265 treatment (40 mg/kg, QD) and diluent control gr...
ORGANISM(S): Homo sapiens 
2012-05-01 | E-GEOD-30812 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of lung cancer cells treated with 5-aza - a genome-wide screen for hypermethylated genes in lung cancer
Abstract; Background: Promoter hypermethylation coupled with loss of heterozygosity at the same locus results in loss of gene function in many tumor cells. The “rules” governing which genes are methylated during the pathogenesis of individual cancers, how specific methylation profiles are init...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-5816 | biostudies-arrayexpress
TranscriptomicsMethylation profiling of human NSCLC promoter regions identifies novel methylation markers for multiple malignancies
BACKGROUND: Promoter hypermethylation coupled with loss of heterozygosity at the same locus results in loss of gene function in many tumor cells. The "rules" governing which genes are methylated during the pathogenesis of individual cancers, how specific methylation profiles are initially establishe...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-6695 | biostudies-arrayexpress
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