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ProteomicsExosomal FABP5 Drives HCC Progression via Macrophage Lipid 1 Metabolism and Immune Microenvironment Remodeling
Introduction: The progression of hepatocellular carcinoma (HCC) is intricately linked to complex interactions within the tumor microenvironment (TME), where the reprogramming of tumor-associated macrophages (TAMs) plays a pivotal role. However, how HCC cells regulate TAM metabolism and function via ...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-12 | PXD068213 | Pride
Lipid metabolism Fatty acid-binding protein 5 Tumor-associated macrophages Exosomes Hepatocellular carcinoma 
MetabolomicsLoss of p53 exacerbates autoimmunity by reprogramming propionyl-CoA metabolism and epigenetics in Treg cells

Metabolic regulation is central to the tumor suppressor function of p53. Here we report that propionyl-CoA metabolic remodeling and epigenetic changes underpin p53-mediated restraint of autoimmunity through regulatory T (Treg) cells. By analyzing the human patients with autoimmune diseases, we fo...

2026-02-06 | MTBLS13473 | MetaboLights
UnknownUmbilical cord mesenchymal stem cells in ulcerative colitis treatment: efficacy and possible mechanisms.
Not available
S-EPMC11368034 | biostudies-literature
ProteomicsIntegrated Proteomic Profiling of Aqueous Humor Reveals CDC42/RHOA-Mediated Pathogenic Mechanisms in nAMD and PDR
Neovascular AMD (nAMD) and proliferative diabetic retinopathy (PDR) are major blinding retinal diseases characterized by pathological angiogenesis. Using data-independent acquisition (DIA) proteomics, we analyzed aqueous humor from nAMD, PDR, and cataract control patients. Among 3186 identified prot...
ORGANISM(S): Homo Sapiens 
PXD068217 |
ProteomicsQuantitative proteomics of EDB-treated APP/PS1 mice
Hippocampal proteins were extracted from the brain tissues of APP+SA and APP+EDB mice. The proteomics experiments and subsequent bioinformatics analysis were supported by OE Biotech Co..
ORGANISM(S): Mus Musculus 
PXD054845 |
ProteomicsMouse Skeletal Muscle Sarcopenia
Our study aimed to characterize sarcopenia in C57BL/6J mice using a clinically relevant definition and age range and investigate the underlying mechanisms leading to sarcopenia. Aged male C57BL/6J mice (23-32 months) were classified as non-sarcopenic (no deficit), probable sarcopenic (1 deficit), an...
ORGANISM(S): Mus Musculus 
2024-08-19 | PXD048723 | panorama
ProteomicsMass spectrometry data of identified proteins of MERS-CoV ORF3 interacting protein
Mass spectrometry data of identified proteins of MERS-CoV ORF3 protein
ORGANISM(S): Homo Sapiens Middle East Respiratory Syndrome-related Coronavirus 
2021-11-28 | PXD030024 |
ProteomicsMass spectrometry data of identified proteins of MERS-CoV ORF4b interacting protein
Mass spectrometry data of identified proteins of MERS-CoV ORF4b protein
ORGANISM(S): Homo Sapiens 
2022-03-06 | PXD032092 |
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