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GenomicsHeterochromatin remodeling by CDK12 contributes to learning in Drosophila
We describe the epigenetic profiling of the H3K9me2 and HP1a in Drosophila third instar larvae before and after CDK12 depletion by RNA interference (RNAi). Here we show that CDK12 regulates heterochromatin dynamics in Drosophila chromosomes. Depletion of CDK12 induces the increased HP1a and H3K9me2 ...
ORGANISM(S): Drosophila melanogaster 
2015-11-02 | E-GEOD-63011 | biostudies-arrayexpress
ProteomicsProteomic analysis of bone marrow-derived macrophages after Nano-IFNγ/Zole and GGPP incubation
We designed and prepared a bisphosphonate-mineralized Nano-IFNγ (Nano-IFNγ/Zole) to promote trans-differentiation of macrophages from the M2 to M1 type. Bisphosphonate in the Nano-IFNγ/Zole reduced lysosomal acidification by inhibiting isoprene modification of Rab family proteins, enhanced tumor ant...
ORGANISM(S): Mus Musculus 
2024-07-05 | PXD053688 |
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