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ProteomicsChanges in composition and levels of hemolymph proteins provide insights to their functions in pharate, early and late pupae and adults of Manduca sexta
The tobacco hornworm, Manduca sexta, is a lepidopteran model species widely used to study insect biochemical processes. While some of its larval hemolymph proteins are well understood, a detailed proteomic analysis was unavailable until 2016, revealing features such as correlation with transcriptome...
ORGANISM(S): Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm) 
2020-10-30 | PXD019392 | Pride
Pupa Hemolymph Manduca sexta Immunity Proteome 
ProteomicsChanges in the plasma proteome of Manduca sexta larvae in relation to the transcriptome variations after an immune challenge: evidence for high molecular weight immune complex formation
Manduca sexta is a lepidopteran model widely used to study insect physiological processes including innate immunity. In this study, we explored the proteomes of cell-free hemolymph from larvae injected with a sterile buffer (C for control) or a mixture of bacteria (I for induced). Of the 654 protein...
ORGANISM(S): Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm) 
2016-02-01 | PXD003267 | Pride
Protein processing Hemolymph proteins Tobacco hornworm Phenoloxidase activation Insect immunity Spectral counting Lc-ms/ms 
MetabolomicsTheabrownin from Pu-erh tea attenuates hypercholesterolemia via modulation of gut microbiota and bile acid metabolism
Pu-erh tea displays cholesterol-lowering properties, but the underlying mechanism has not been elucidated. Theabrownin is one of the most active and abundant pigments in Pu-erh tea. Here, we show that theabrownin alters the gut microbiota in mice and humans, predominantly suppressing microbes associ...
2021-11-18 | MTBLS1259 | MetaboLights
TranscriptomicsExpression profiling of primary glioma samples
Background: Signaling by receptor tyrosine kinases (RTK) is frequently dysregulated in gliomas. Inter-individual variability in the causes for dysregulated RTK signaling may have hampered the efficacy of targeted therapies. Using gene expression modules around key regulators in the RAS-RAF-MEK-MAPK ...
ORGANISM(S): Homo sapiens 
2015-10-30 | E-GEOD-74462 | biostudies-arrayexpress
ProteomicsSUMOylation fine tunes the transcriptional activity of endothelial HEY1 in the regulation of angiogenesis
Reversible HEY1 SUMOylation is a molecular mechanism that coordinates endothelial angiogenic signaling and angiogenesis, both in physiological and pathological milieus, by fine tuning the transcriptional activity of HEY1. Specifically, S UMOylation facilitates the formation of the HEY1 transcription...
ORGANISM(S): Homo Sapiens 
2023-08-18 | PXD044611 |
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