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ProteomicsTetramethylpyrazine improves cognitive impairment and modifies the hippocampal proteome in two mouse models of Alzheimer's disease
Alzheimer's disease (AD) is one of the most common neurodegenerative diseases. So far, there is no effective treatment for this condition. Tetramethylpyrazine (TMP) is an alkaloid extracted from traditional Chinese medicine chuanxiong, which is mainly used in the treatment of ischemic stroke some re...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD022862 | Pride
Tetramethylpyrazine  alzheimer’s disease (ad)  proteomics  mitochondria  oxphos 
ProteomicsTetramethylpyrazine improves cognitive impairment and modifies the hippocampal proteome in two mouse models of Alzheimer's disease
Alzheimer's disease (AD) is one of the most common neurodegenerative diseases. So far, there is no effective treatment for this condition. Tetramethylpyrazine (TMP) is an alkaloid extracted from traditional Chinese medicine chuanxiong, which is mainly used in the treatment of ischemic stroke some re...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD022840 | Pride
Tetramethylpyrazine  alzheimer’s disease (ad)  proteomics  mitochondria  oxphos 
ProteomicsDiscovery of Novel MLKL PROTAC Degrader for the Treatment of Hepatocellular Carcinoma via Promoting Parthanatos
Chen et al. discovered a highly potent and selective MLKL-targeted PROTAC C116 that effectively induces MLKL degradation and promotes parthanatos in HCC cells. More significantly, C116 was able to induce in vivo MLKL degradation and exerts anti-tumor activities in an orthotopic HCC tumor model, posi...
ORGANISM(S): Mus Musculus 
PXD069462 |
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