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The pathophysiology of Alzheimer’s disease (AD) is multifactorial with characteristic extracellular accumulation of amyloid-beta (Aβ) and intraneuronal aggregation of hyperphosphorylated tau in the brain. Development of disease-modifying treatment for AD has been challenging. Recent studies suggest ...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-10 | PXD039514 | Pride
Tetramethylpyrazine (TMP) has shown potential in the treatment of acute respiratory infections. We used single-cell RNA sequencing to investigate the mechanism and potential therapeutic effect of TMP in the treatment of acute lung injury
ORGANISM(S): Mus musculus 
2024-10-29 | GSE276682 | GEO
Genomics
Bacillus producing tetramethylpyrazine
Alzheimer's disease (AD) is one of the most common neurodegenerative diseases. So far, there is no effective treatment for this condition. Tetramethylpyrazine (TMP) is an alkaloid extracted from traditional Chinese medicine chuanxiong, which is mainly used in the treatment of ischemic stroke some re...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD022840 | Pride
Alzheimer's disease (AD) is one of the most common neurodegenerative diseases. So far, there is no effective treatment for this condition. Tetramethylpyrazine (TMP) is an alkaloid extracted from traditional Chinese medicine chuanxiong, which is mainly used in the treatment of ischemic stroke some re...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD022862 | Pride
Genomics
Tetramethylpyrazine and B. pseudolongum-driven taurine metabolism
Single-cell transcriptome analysis revealed cellular reprogramming following Tetramethylpyrazine treatment in LPS-induced acute lung injury
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