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ProteomicsLarge Extracellular Vesicles Derived from LPS-preconditioned Cardiomyocytes Alleviate Myocarditis via Mediating Macrophage Polarization and Modulating p38 MAPK Pathway
Myocarditis is an inflammatory injury to the myocardium characterized by disrupted intercellular communication, involving macrophages and cardiomyocytes as key players. However, the interactions between macrophages and cardiomyocytes during myocarditis remain inadequately explored. Emerging evidence...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-09-29 | PXD057460 | Pride
Myocarditis cardiomyocytes  macrophages  large extracellular vesicles 
ProteomicsRapamycin targets RBBP7 to regulate histone H4 acetylation and suppress hepatocellular carcinoma.
Identifying therapeutic protein targets is challenging due to unpredictable druggability. Exploring multi-purpose drug targetomes, such as that of rapamycin, offers a valuable strategy for target discovery. Here, using chemical proteomics, we identified the histone-binding protein RBBP7 as a previou...
ORGANISM(S): Homo Sapiens 
2026-07-13 | PXD080960 |
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