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ProteomicsLarge Extracellular Vesicles Derived from LPS-preconditioned Cardiomyocytes Alleviate Myocarditis via Mediating Macrophage Polarization and Modulating p38 MAPK Pathway
Myocarditis is an inflammatory injury to the myocardium characterized by disrupted intercellular communication, involving macrophages and cardiomyocytes as key players. However, the interactions between macrophages and cardiomyocytes during myocarditis remain inadequately explored. Emerging evidence...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-09-29 | PXD057460 | Pride
Myocarditis cardiomyocytes  macrophages  large extracellular vesicles 
GenomicsDilated cardiomyopathy vs Myocarditis
Dilated cardiomyopathy vs Myocarditis
PRJNA493608 | ENA
TranscriptomicsComparative cardiac transcriptomics of immune checkpoint inhibitor induced myocarditis
Immune checkpoint inhibitors (ICIs) are improving cancer treatments strikingly. The raising use leads to the augmented occurrence of immune related events. Myocarditis is a rare, but severe form of these adverse events. Nine patients with proven ICI induced myocarditis were subjected to myocardial b...
ORGANISM(S): Homo sapiens 
2020-11-01 | E-MTAB-8867 | biostudies-arrayexpress
ProteomicsUsing proteomics and transcriptomics to explore the potential gene regulatory network of immune checkpoint inhibitors-related myocarditis
Immune checkpoint inhibitor-related myocarditis is the deadliest complication of immunotherapy. However, the underlying pathophysiological mechanisms of its occurrence and development remain unclear. Due to the long-term lack of effective early diagnosis and treatment options, it is of great signifi...
ORGANISM(S): Homo Sapiens 
2023-02-02 | PXD039793 |
TranscriptomicsMicroRNA155 mediates adverse inflammation in acute viral myocarditis LNA-antimiR155 treatment
For microRNA knockdown in vivo, a 15-mer LNA-antimiR oligonucleotide targeting mmu-miR-155 or an LNA control was administered to male 4-week-old C3H mice intravenously at a dose of 25 mg/kg per injection at days 1, 4 and 6 post-CVB3 infection. Samples were taken at 6 days post infection.
ORGANISM(S): Mus musculus 
2012-06-06 | E-MEXP-3395 | biostudies-arrayexpress
ProteomicsTherapeutic effect of platelet-derived extracellular vesicles on viral myocarditis correlate with biomolecular content
Extracellular vesicles (EVs) can potently inhibit inflammation yet there is a lack of understanding about the impact of donor characteristics on the efficacy of EVs. The goal of this study was to determine whether the sex and age of donor platelet-derived EVs (PEV) affected their ability to inhibit ...
ORGANISM(S): Homo sapiens (Human) 
2024-12-30 | PXD058698 | Pride
Human Platelet Viral Myocarditis Vesicles Extracellular Pmpev Pev 
UnknownTelemedicine in myocarditis: Evolution of a mutidisciplinary "disease unit" at the time of COVID-19 pandemic.
Not available
S-EPMC7419248 | biostudies-literature
ProteomicsCrocins ameliorate experimental immune checkpoint inhibitor-related myocarditis by targeting the Hpx/Nrf2/HO-1 pathway
Immune checkpoint inhibitors (ICIs) for cancer therapy may induce immune-related adverse events including myocarditis, which occurs infrequently but carries a high mortality rate. Crocins are the active constituents derived from Crocus sativus L. (Saffron), and have demonstrated various bioactivitie...
ORGANISM(S): Mus Musculus 
2025-12-27 | PXD072469 |
TranscriptomicsExpression profiles of non-coding RNAs in the heart of mice with coxsackie B3 virus-induced myocarditis
Non-coding RNAs (ncRNAs) are critical regulators of viral infection and inflammatory responses. However, the roles of ncRNAs in acute myocarditis (AM)M) remain unclear.To identify ncRNAs involved in viral myocarditis pathogenesis by RNA-seq.
ORGANISM(S): Mus musculus 
2021-08-16 | E-MTAB-10823 | biostudies-arrayexpress
TranscriptomicsSex differences during acute myocarditis against coxsackievirus B3 (CVB3)-induced myocarditis (10 dpi) and chronic myocarditis/dilated cardiomyopathy (DCM) against CVB3-induced myocarditis (90 dpi)
Men are at an increased risk of dying from heart failure caused by inflammatory heart diseases such as atherosclerosis, myocarditis and dilated cardiomyopathy (DCM). We previously showed that immune responses in the heart are phenotypically distinct in male compared to female mice 10 days after infe...
ORGANISM(S): Mus musculus 
2012-01-19 | E-GEOD-35182 | biostudies-arrayexpress
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