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TranscriptomicsConjugated linoleic acid activates AMPK and reduces adiposity more effectively when used with metformin
Trans-10, cis-12 conjugated linoleic acid (t10c12 CLA) causes dramatic reductions in white adipose tissue in mice but has had limited effectiveness in humans. Determination of the signaling pathways involved may lead to better regulation of adiposity. T10c12 CLA was found to activate AMP-activating...
ORGANISM(S): Mus musculus 
2009-11-01 | E-GEOD-14888 | biostudies-arrayexpress
TranscriptomicsActivated AMPK and prostaglandins are involved in the response to conjugated linoleic acid and are sufficient to cause lipid reductions in adipocytes
Activated AMPK and prostaglandins are involved in the response to conjugated linoleic acid and are sufficient to cause lipid reductions in adipocytes. Trans-10, cis-12 conjugated linoleic acid (t10c12 CLA) reduces triglyceride levels in adipocytes. AMP-activated protein kinase (AMPK) was recently de...
ORGANISM(S): Mus musculus 
2010-08-10 | E-GEOD-17404 | biostudies-arrayexpress
TranscriptomicsComparison of transcriptome profile between wild-type and dao mutant plants
We identified and characterized that the rice Dioxygenase for Auxin Oxidation (dao) mutant displays pleiotropic phenotypes, including indehiscent anthers, sterile pollens, and increased free IAA levels in anthers.We conclude that DAO-mediated auxin catabolism is essential for auxin homeostasis and l...
ORGANISM(S): Oryza sativa Japonica Group 
2012-09-25 | E-GEOD-41097 | biostudies-arrayexpress
ProteomicsIntegrated proteomic and metabolomic profile analyses of cardiac valves revealed molecular mechanisms and targets in calcific aortic valve disease
This study aimed to define changes in the metabolic and protein profiles of patients with calcific aortic valve disease (CAVD).
ORGANISM(S): Homo Sapiens 
2022-09-19 | PXD036839 |
MetabolomicsSensing Ceramides by CYSLTR2 and P2RY6 to Aggravate Atherosclerosis

Recent evidence shows elevated circulating long-chain ceramide levels predicts atherosclerotic cardiovascular disease (ASCVD) independently of cholesterol. Although targeting ceramides signaling may provide therapeutic benefits beyond the treatment of hypercholesterolemia, the underlying mechanis...

2025-04-15 | MTBLS11925 | MetaboLights
ProteomicsBis(zinc(II)-dipicolylamine) functionalized sub-2 μm core-shell microspheres enabled comprehensive analysis of N-phosphoproteome
Herein, bis(zinc(II)-dipicolylamine) functionalized sub-2 μm core-shell silica microspheres (SiO2@DpaZn) were tailored for N-phosphopeptide enrichment at pH 7.7. Contributed by the coordination bonding between Zn(II) and phosphate groups with the KD value of 13.14 μM, N-phosphopeptides could be capt...
ORGANISM(S): Escherichia Coli 
2020-02-07 | PXD017423 |
ProteomicsBis(zinc(II)-dipicolylamine) functionalized sub-2 μm core-shell microspheres for analysis of N-phosphoproteome-
Herein, bis(zinc(II)-dipicolylamine) functionalized sub-2 μm core-shell silica microspheres (SiO2@DpaZn) were tailored for N-phosphopeptide enrichment at pH 7.7. Contributed by the coordination bonding between Zn(II) and phosphate groups with the KD value of 13.14 μM, N-phosphopeptides could be capt...
ORGANISM(S): Homo Sapiens 
PXD021067 |
UnknownPrevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study.
Not available
S-EPMC7880913 | biostudies-literature
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