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TranscriptomicsGenome-wide analysis of parental and wild-type SK-N-Be(2)C neuroblastoma cell lines as well as those co-treated with the histone deacetylase inhibitor SAHA
Analysis of varied biologic pathways in neuroblastoma SK-N-Be(2)C cells grown in doxorubicin and/or SAHA. We hypothesized that SK-N-Be(2)C cells undergo a mesenchymal change through mesenchymal change resulting in a more invasive as well as drug resistant phenotype, and that the mechanism of SAHAs e...
ORGANISM(S): Homo sapiens 
2016-05-31 | E-GEOD-47669 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of derived doxorubicin resistant neuroblastoma SK-N-Be(2)C and SK-N-SH cell lines
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2016-05-31 | E-GEOD-47670 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse embryonic stem cell line mESC D3 reveals cardiac differentiation of embryonic stem cells recapitulates embryonic cardiac development.
Mouse embryonic stem cells can differentiate in vitro into spontaneously contracting cardiomyocytes. The main objective of this study was to investigate cardiogenesis in cultures of differentiating embryonic stem cells (ESCs) and to determine how closely it mimics in vivo cardiac development. We ide...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-5671 | biostudies-arrayexpress
TranscriptomicsKidney gene expression profile following the transplant-induced reactivation of MCMV
Reactivation of latent HCMV is a significant infectious complication of organ transplantation, and current therapies target viral replication once reactivation of transcriptionally silent, latent virus has already occurred. The specific molecular pathways that activate viral gene expression are not...
ORGANISM(S): Mus musculus 
2015-08-27 | E-GEOD-72392 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human CD4+ T cells from HIV infected individuals vs. controls reveals type I interferon-mediated disruption of T cell dynamics
The mechanism of CD4(+) T cell depletion during chronic human immunodeficiency virus type 1 (HIV-1) infection remains unknown. Many studies suggest a significant role for chronic CD4(+) T cell activation. We assumed that the pathogenic process of excessive CD4(+) T cell activation would be reflected...
ORGANISM(S): Homo sapiens 
2008-04-07 | E-GEOD-9927 | biostudies-arrayexpress
TranscriptomicsGlobal Gene Expression Profiling in wildtype and PAI-1 Knockout Murine Heart and Kidney.
Fibrosis is defined as an abnormal matrix remodeling and loss of tissue homeostasis due to excessive synthesis and accumulation of extracellular matrix proteins in tissues. At present, there is no effective therapy for organ fibrosis. Previous studies demonstrated that aged plasminogen activator inh...
ORGANISM(S): Mus musculus 
2014-04-23 | E-GEOD-46320 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of gene expression of Flk1Cre;ETV2 CKO mouse yolk sacs.
To identify genes critical for vascular development, we generated mice where ETV2 is inactivated in FLK1+ cells by a loxP-Cre recombination approach. Results provide a detailed insight into the function of ETV2 in emrbyonic vasculare formation. Total RNA obtained from E9.5 yolk sacs from Flk1Cre;ET...
ORGANISM(S): Mus musculus 
2014-11-17 | E-GEOD-51407 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of parental wild-type and derived doxorubicin resistant SK-N-SH neuroblastoma cell lines as well as those co-treated with the histone deacetylase inhibitor SAHA
Analysis of varied biologic pathways in neuroblastoma SK-N-SH cells grown in doxorubicin and/or SAHA. The hypothesis was that SK-N-SH cells undergo a mesenchymal change through mesenchymal change resulting in a more invasive as well as drug resistant phenotype, and that the mechanism of SAHAs effect...
ORGANISM(S): Homo sapiens 
2016-05-31 | E-GEOD-47668 | biostudies-arrayexpress
TranscriptomicsDifferential gene regulation by miR-142-3p and miR-K10a isomiRs
This study compares changes in gene expression induced by four interrelated miRNAs with similar but staggered 5'-ends: miR-142-3p, miR-142-3p-1, miR-K10a, and miR-K10a+1. miR-K10a and miR-K10a+1 are co-expressed by the Kaposi's sarcoma-associated herpesvirus. Total RNA was harvested from HEK293 cell...
ORGANISM(S): Homo sapiens 
2015-07-31 | E-GEOD-66489 | biostudies-arrayexpress
TranscriptomicsIdentification of p38 beta as a therapeutic target for the treatment of Sézary Syndrome
Cutaneous T-Cell Lymphomas (CTCL) represent a group of hematopoietic malignancies that home to the skin and have no known molecular basis for disease pathogenesis. Sézary syndrome (SS) is the leukemic variant of CTCL. Currently, CTCL is incurable, highlighting the need for new therapeutic modalitie...
ORGANISM(S): Homo sapiens 
2015-07-01 | E-GEOD-59179 | biostudies-arrayexpress
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