This project primarily investigates the interactome of SNX18, a key mediator protein in the degradation of extracellular vesicles (EVs), as well as the degradation efficiency of EGFR and PDL1 using an SNX18-LIR motif-based overexpression platform for targeted protein degradation.
To identify the proteins within the EVs that play major roles in mediating EV sorting into lysosomes, we used a biotin-labelled method to monitor the proteomic change associated with EVs during their degradation.
