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MetabolomicsPla2g7 regulates bone homeostasis via Alox12/12-HETE/Gpr31 signaling axis

Bone homeostasis mainly depends on the equilibrium of osteoclasts and osteoblasts, overactivated osteoclasts play a pivotal role in the progression of osteoporosis. Here, we revealed that Pla2g7 (phospholipase A2 group VII) was positively correlated with bone resorption in clinic. By single-cell ...

2025-10-30 | MTBLS13141 | MetaboLights
TranscriptomicsAMD3100 and G-CSF Mobilize Different CD34+ Cell Populations Based on Gene and miRNA Expression
Plerixafor (AMD3100) and G-CSF mobilize peripheral blood stem cells (PBSCs) by different mechanisms. A rhesus macaque model was used to compare plerixafor and G-CSF-mobilized CD34+ cells. Three PBSC concentrates were collected from 3 macaques treated with G-CSF, plerixafor, or plerixafor plus G-CSF....
ORGANISM(S): Macaca mulatta 
2009-12-04 | E-GEOD-16936 | biostudies-arrayexpress
TranscriptomicsApelin/APJ signaling mediated by G alpha 13 and MEF2 in endothelial cells
Evaluation of gene transcripts that are downstream of apelin/APJ signaling in HUVECs Duplicates per group, subjected to: 1) control siRNA, 2) MEF2A and MEF2C siRNA, 3) G alpha 13 siRNA, and 4) apelin and APJ siRNA
ORGANISM(S): Homo sapiens 
2013-05-11 | E-GEOD-46825 | biostudies-arrayexpress
GenomicsseCLIP of C. elegans EIF-3.G in the cholinergic motor neurons
seCLIP of C. elegans EIF-3.G in the cholinergic motor neurons
PRJNA640155 | ENA
ProteomicsAnalysis of proteins in supernatant and precipitate fractions of human bronchial smooth muscle cells by 1D SDS-PAGE and quantitative LC-MS/MS
Supernatant and precipitate protein fractions of human bronchial smooth muscle cells (HBSMC) after sonication and centrifugation were analyzed using 1D SDS-PAGE. The gel lanes were cube-cut into thirty-three 1.1 mm x 1.1 mm x 1 mm (gel thickness) squares and each gel piece was subjected to in-gel d...
ORGANISM(S): Homo sapiens (Human) 
2019-01-03 | PXD010036 | Pride
Precipitation fraction 1d sds-page Supernatant fraction Bronchial smooth muscle cells Quantitative lc-ms/ms 
ProteomicsTargeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor
G protein-coupled receptors (GPCRs) activate heterotrimeric G proteins by mediating a GDP to GTP exchange in the Gα subunit. This leads to dissociation of the heterotrimer into Gα-GTP and Gβγ dimer. The Gα-GTP and Gβγ dimer each regulate a variety of downstream pathways to control various aspects of...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-19 | PXD009503 | Pride
Lc-ms 
GenomicsChromatin architecture organized by histone variants H3.3 and H2A.Z in the human genome
To understand how chromatin structure is organized by different histone variants, we have measured the genome-wide distribution of nucleosome core particles (NCPs) containing the histone variants H3.3 and H2A.Z in human cells. We find that a special class of NCPs containing both variants is enriched...
ORGANISM(S): Homo sapiens 
2009-07-26 | E-GEOD-13308 | biostudies-arrayexpress
GenomicsChIP-Sequencing of AL5 over-expressing Arabidopsis and its knock out mutant
Plant homeodomain (PHD) finger proteins affect growth and development by regulating transcription and reading epigenetic modifications of histones, but their functions in abiotic stress responses remain largely unclear. Here we characterize seven Arabidopsis thaliana Alfin1-like PHD finger proteins ...
ORGANISM(S): Arabidopsis thaliana 
2014-04-12 | E-GEOD-56706 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of aluminum toxicity and tolerance responses in maize roots
Aluminum (Al) toxicity is a major factor limiting crop yields on acid soils. In maize, Al tolerance is a complex phenomenon involving multiple genes and physiological mechanisms yet uncharacterized. To begin elucidating the molecular basis of maize Al toxicity and tolerance, we performed a detailed ...
ORGANISM(S): Zea mays 
2010-05-26 | E-GEOD-10308 | biostudies-arrayexpress
TranscriptomicsDiscovery and profiling conserved and novel miRNAs involved in ovule development of Ginkgo biloba by deep sequencing
High-throughput small RNA sequencing were performed to identify a large number of miRNAs and their targets in mature G. biloba ovules. Our study is the first to provide useful information for uncovering the regulatory networks of miRNAs in basal gymnosperm G. biloba ovules. small RNA sequencing in...
ORGANISM(S): Ginkgo biloba 
2016-02-12 | E-GEOD-74024 | biostudies-arrayexpress
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