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UnknownA Type VI Secretion System Facilitates Fitness, Homeostasis, and Competitive Advantages for Environmental Adaptability and Efficient Nicotine Biodegradation.
Gram-negative bacteria employ secretion systems to translocate proteinaceous effectors from the cytoplasm to the extracellular milieu, thus interacting with the surrounding environment or microniche. It is known that bacteria can benefit from the type VI secretion system (T6SS) by transporting ions ...
S-EPMC8091027 | biostudies-literature
UnknownTreat-to-target versus high-intensity statin treatment in patients with or without diabetes mellitus: a pre-specified analysis from the LODESTAR trial.

Background

The impact of titrated versus fixed intensity statin therapy in patients with coronary artery disease (CAD) and diabetes mellitus (DM) remains to be elucidated.

Methods

This was a pre-specified analysis of patients with and without DM from the LODESTAR trial. Patients with ...
S-EPMC10520306 | biostudies-literature
UnknownDispersals of the Siberian Y-chromosome haplogroup Q in Eurasia.
The human Y-chromosome has proven to be a powerful tool for tracing the paternal history of human populations and genealogical ancestors. The human Y-chromosome haplogroup Q is the most frequent haplogroup in the Americas. Previous studies have traced the origin of haplogroup Q to the region around ...
S-EPMC5846874 | biostudies-literature
UnknownA new infrageneric classification of Gastrochilus (Orchidaceae: Epidendroideae) based on molecular and morphological data.
Gastrochilus is an orchid genus containing 73 species of mainly epiphytic on trees or rocks in mountain forests of tropical and subtropical Asia. Previous phylogenetic analyses and morphological assessments have failed to produce a well-resolved phylogeny at the infrageneric level. In the pre...
S-EPMC11390603 | biostudies-literature
UnknownArsenic trioxide replacing or reducing chemotherapy in consolidation therapy for acute promyelocytic leukemia (APL2012 trial).
As all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) are widely accepted in treating acute promyelocytic leukemia (APL), deescalating toxicity becomes a research hotspot. Here, we evaluated whether chemotherapy could be replaced or reduced by ATO in APL patients at different risks. Af...
S-EPMC8017727 | biostudies-literature
UnknownTuning Gas Sensor Selectivity via Morphological Engineering of Au Catalysts on TiO<sub>2</sub>-based Nanosheets.
Recent studies on catalyst development have primarily focused on discovering novel catalyst compositions, rather than exploiting the morphology and interface effects of existing catalytic materials. This study develops a novel material-driven gas sensor selectivity strategy by tailoring the surface ...
S-EPMC12674107 | biostudies-literature
UnknownMyotonia congenita: novel mutations in CLCN1 gene.
Myotonia congenita belongs to the group of non-dystrophic myotonia caused by mutations of CLCN1gene, which encodes human skeletal muscle chloride channel 1. It can be inherited either in autosomal dominant (Thomsen disease) or recessive (Becker disease) forms. Here we have sequenced all 23 exons and...
S-EPMC4826137 | biostudies-literature
UnknownB-cell Function Gene Mutations in Diffuse Large B-cell Lymphoma: A Retrospective Cohort Study.
Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous subtype of non-Hodgkin lymphoma. In addition to clinical and immunophenotypic characteristics, recurrent gene mutations have recently been identified in patients with DLBCL using next-generation sequencing technologies. The aim of this study i...
S-EPMC5474506 | biostudies-literature
UnknownEffect of rosuvastatin versus atorvastatin on new-onset diabetes mellitus in patients treated with high-intensity statin therapy for coronary artery disease: a post-hoc analysis from the LODESTAR randomized clinical trial.

Background

The impact of rosuvastatin versus atorvastatin on new-onset diabetes mellitus (NODM) among patients treated with high-intensity statin therapy for coronary artery disease (CAD) remains to be clarified. This study aimed to evaluate the risk of NODM in patients with CAD treated with...
S-EPMC11304915 | biostudies-literature
UnknownACE2 pathway regulates thermogenesis and energy metabolism.
Identification of key regulators of energy homeostasis holds important therapeutic promise for metabolic disorders, such as obesity and diabetes. ACE2 cleaves angiotensin II (Ang II) to generate Ang-(1-7) which acts mainly through the Mas1 receptor. Here, we identify ACE2 pathway as a critical regul...
S-EPMC8776250 | biostudies-literature
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