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TranscriptomicsTranscriptomes of Alveolar epithelial cells
Freshly isolated type I and type II alveolar epithelial cells were investigated for transcriptomes with dual-color DNA microarray using 3DNA 50 kit.
ORGANISM(S): Rattus norvegicus 
2010-06-11 | E-GEOD-2160 | biostudies-arrayexpress
TranscriptomicsGene expression profiles in AEC II during hyperoxia exposure and recovery
In this study, type II alveolar epithelial cells (AEC II) were isolated from normal, hyperoxia exposed (day 0) and recovery (day 1,3,5 and 7) rats with high purity (~95%). Total RNA from isolated cells were used for dual color DNA microarray hybridization with 3DNA 50 kit version 2. Keywords: time-c...
ORGANISM(S): Rattus norvegicus 
2010-06-11 | E-GEOD-2707 | biostudies-arrayexpress
TranscriptomicsArsenic-induced Changes in L2 Cells
Arsenic is a carcinogen that is known to induce cell transformation and tumor formation. Although studies have been performed to examine the modulation of signaling molecules caused by arsenic exposure, the molecular mechanisms by which arsenic causes cancer are still unclear. We hypothesized that ...
ORGANISM(S): Rattus norvegicus 
2011-12-23 | E-GEOD-9790 | biostudies-arrayexpress
TranscriptomicsErbB2 Pathway Activation upon Smad4 Loss Promotes Lung Tumor Growth and Metastasis [expression]
Lung cancer remains the leading cause of cancer death. Genome sequencing of lung tumors from patients with Squamous Cell Carcinoma has identified SMAD4 to be frequently mutated. Here we used a novel mouse model to determine the molecular mechanisms regulated by loss of Smad4 which lead to lung cance...
ORGANISM(S): Mus musculus 
2015-03-05 | E-GEOD-57133 | biostudies-arrayexpress
GenomicsErbB2 Pathway Activation upon Smad4 Loss Promotes Lung Tumor Growth and Metastasis [ChIP-seq]
Lung cancer remains the leading cause of cancer death. Genome sequencing of lung tumors from patients with Squamous Cell Carcinoma has identified SMAD4 to be frequently mutated. Here we used a novel mouse model to determine the molecular mechanisms regulated by loss of Smad4 which lead to lung cance...
ORGANISM(S): Mus musculus 
2015-03-05 | E-GEOD-57177 | biostudies-arrayexpress
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