Arsenic-induced Changes in L2 Cells

ABSTRACT: Arsenic is a carcinogen that is known to induce cell transformation and tumor formation. Although studies have been performed to examine the modulation of signaling molecules caused by arsenic exposure, the molecular mechanisms by which arsenic causes cancer are still unclear. We hypothesized that arsenic alters gene expression leading to carcinogenesis in the lung. In this study, we examined global gene expression in response to 0.75 M-BM-5M arsenic treatment for 1-7 days in a rat lung epithelial cell line (L2) using an in-house 10k rat DNA microarray. One hundred thirty one genes were identified using the one-class statistical analysis of microarray (SAM) test. Of them, 33 genes had a fold change of M-bM-^IM-% 2 at least between two time points. These genes were then clustered into 5 g

ORGANISM(S): Rattus norvegicus

SUBMITTER: Tingting Weng 

PROVIDER: E-GEOD-9790 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress