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MetabolomicsThe trans-omics landscape of COVID-19
The outbreak of coronavirus disease 2019 (COVID-19) is a global health emergency. Various omics results have been reported for COVID-19, but the molecular hallmarks of COVID-19, especially in those patients without comorbidities, have not been fully investigated. Here we collect blood samples from 2...
2021-10-06 | MTBLS2542 | MetaboLights
ProteomicsDiscovery and validation of lung cancer biomarkers based on proteomic analysis of bronchoalveolar lavage fluid from the self-controlled pulmonary lobe
Background: Distinguishing indeterminate pulmonary nodules remains a significant challenge in the early diagnosis of lung cancer, while proteomic biomarkers derived from the lesioned pulmonary lobe may provide crucial insights into their malignant progression. Methods: Our study cohort included thre...
ORGANISM(S): Homo Sapiens 
2025-11-25 | PXD071235 |
ProteomicsZhizi Chi (Gardeniae Fructus and Semen Sojae Praeparatum) Decoction attenuates anxious depression via modulation of intestinal bacteria and reward nerve center
This study aimed to explain the mechanism of ZZCD in treating anxious depression from the perspective of the brain-gut axis by constructing multiple connections between the nucleus accumbent (NAc) and intestinal flora in anxiety-depressed mice.
ORGANISM(S): Gardenia Jasminoides 
2023-03-07 | PXD040673 |
ProteomicsModified Sanjia Powder Ameliorates Cognitive Impairment and Exerts Neuroprotective Effects in 5×FAD Mice: Insights from Quantitative Proteomics
Proteomics reveals Sanjia neuroprotection mechanisms
ORGANISM(S): Mus Musculus 
2025-12-26 | PXD072435 |
ProteomicsLow-dose metformin targets the lysosome-AMPK pathway through PEN2
Metformin is the most prescribed anti-diabetic medicine, and has also been shown to have other various benefits, such as anti-aging and anti-cancer effects. For clinical doses of metformin, it is known that AMPK plays a major role; however, the direct molecular target of metformin remains unclear. H...
ORGANISM(S): Homo Sapiens Mus Musculus 
2021-12-01 | PXD030090 |
ProteomicsLithocholic acid targets TULP3-Sirtuins to deacetylate v-ATPase and activate AMPK
Lithocholic acid (LCA), accumulated in mammals during calorie restriction (CR), can activate AMP-activated protein kinase (AMPK) and slow down ageing1. However, how LCA is signalled to activate AMPK and elicit the biological effects is unclear. Here, we show that LCA can enhance the activity of sirt...
ORGANISM(S): Homo Sapiens Mus Musculus 
2024-09-16 | PXD056134 |
ProteomicsThe aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK
The activity of 5’-adenosine monophosphate-activated protein kinase (AMPK) is inversely correlated with the cellular availability of glucose. When glucose levels are low, the glycolytic enzyme aldolase is not bound to fructose-1,6-bisphosphate (FBP) and, instead, signals to activate lysosomal AMPK. ...
ORGANISM(S): Oryctolagus Cuniculus 
2022-08-10 | PXD035968 |
UnknownPrevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study.
Not available
S-EPMC7880913 | biostudies-literature
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