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TranscriptomicsDual Roles of Histone H3 Lysine 9 Acetylation in Human Embryonic Stem Cell Pluripotency and Neural Differentiation
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2015-03-11 | E-GEOD-66779 | biostudies-arrayexpress
TranscriptomicsRNA-seq analysis of gene expression patterns responding to TSA treatment during hESC neural differentiation
We report the differential roles of an HDAC inhibitor-TSA during hESC nerual commitment. In the initiation of hESC differentiation, TSA could inhibit the downregulation of pluripotency genes to maintain pluripotency, whereas in the neural commitment stage, TSA could promote neural gene expression to...
ORGANISM(S): Homo sapiens 
2015-03-11 | E-GEOD-66777 | biostudies-arrayexpress
GenomicsChIP-seq analysis of H3K9 acetylation enrichment in hESCs and day 8 neural progenitor cells
H3K9 acetylation was enriched in pluripotency genes in hESCs and in neural genes in neural progenitor cells Examination of H3K9 acetylation distributions in hESCs and neural progenitor cells
ORGANISM(S): Homo sapiens 
2015-03-11 | E-GEOD-66778 | biostudies-arrayexpress
GenomicsGenome-wide ChIP-seq analysis of Pou3f1 during mouse pluripotent stem cell neural fate commitment
Appropriate neural initiation of the pluripotent stem cells in the early embryos is critical for the development of the central nervous system. This process is regulated by the coordination of extrinsic signals and intrinsic programs. However, how the coordination is achieved to ensure proper neural...
ORGANISM(S): Mus musculus 
2015-11-23 | E-GEOD-69778 | biostudies-arrayexpress
TranscriptomicsStereo-sequencing: 3D Transcriptome of the mouse embryo at gastrulation
To glean an appreciation of the holistic genetic activity in the gastrulating mouse embryo, we performed a genome-wide spatial transcriptome analysis (Stereo-seq), using a low-cell number sequencing protocol on laser microdissected samples of epiblast cells with retained positional address. The 3D t...
ORGANISM(S): Mus musculus 
2016-03-24 | E-GEOD-65924 | biostudies-arrayexpress
TranscriptomicsRole of Pou3f1 during mouse pluripotent stem cell neural fate commitment
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2015-06-15 | E-GEOD-69865 | biostudies-arrayexpress
GenomicsExpression and epigenetic profiling during mouse ESC neural differentiation
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2015-02-19 | E-GEOD-66027 | biostudies-arrayexpress
TranscriptomicsGene expression analysis in differentiated day 3 cells from mouse ESC under the treatment of DMSO and histone deacetylase inhibitors (TSA) [expression array]
Based on the cDNA microarrays performed with the RNAs prepared from the differentiated cells at day 3 with or without 24 hrs TSA treatment initiated at day 2, we reveal that the upregulated gene sets were highly enriched for biological functions related to mesoderm development, mesoderm morphogenesi...
ORGANISM(S): Mus musculus 
2015-02-19 | E-GEOD-66026 | biostudies-arrayexpress
GenomicsGenome-wide anaylsis of histone acetylation during mouse ESC differentiation [ChIP-seq]
Using acetylated histone H3 ChIP-seq, we reveal that the histone H3 acetylation level is gradually increased on the neural gene loci while decreased on the neural-inhibitory gene loci during mouse ESC neural differentiation. By overlapping with the targets of HDAC1 ChIP-seq, we identify Nodal as a t...
ORGANISM(S): Mus musculus 
2015-02-19 | E-GEOD-66025 | biostudies-arrayexpress
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