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ProteomicsTissue extracellular matrix hydrogels as alternative to Matrigel for culturing gastrointestinal organoid
Matrigel, a mouse tumor extracellular matrix (ECM) protein mixture, is an indispensable component of most organoid tissue culture. However, it has limited the utility of organoids for drug development and regenerative medicine due to its tumor-derived origin, batch-to22 batch variation, high cost, a...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2022-01-31 | PXD023705 | Pride
Gastrointestinal organoid Tissue extracellular matrix 
ProteomicsAn integrative multi-omics approach to characterize prebiotic inulin effects on Faecalibacterium prausnitzii
Faecalibacterium prausnitzii, a major commensal bacterium in the human gut, is well known for its anti-inflammatory effects, which improve host intestinal health. Although several studies have reported that inulin, a well-known prebiotic, increases the abundance of F. prausnitzii in the intestine, t...
ORGANISM(S): Faecalibacterium prausnitzii A2-165 Bacteria 
2022-04-04 | PXD030078 | Pride
Prebiotics Pts transporter Beta-fructosidase Abc transporter Faecalibacterium prausnitzii Amylosucrase Inulin Lc-ms/ms 
ProteomicsUnveiling the inhibition mechanism of Clostridioides difficile by Bifidobacterium longum via multiomics approach
A major risk factor for Clostridioides difficile infection (CDI) is the perturbation of the gut microbiota by antibiotic administration, and antibiotic therapy, the standard treatment option for CDI, exacerbates the imbalance of the gut microbiota, leading to a very high recurrent CDI (rCDI) inciden...
ORGANISM(S): Clostridioides difficile ATCC 9689 = DSM 1296 
2024-01-26 | PXD040738 | Pride
Metabolomics Microbe-microbe interaction Clostridioides difficile Molecular mechanism. Bifidobacterium longum Proteomics 
ProteomicsCombination of a microfluidic device with brain extracellular matrix promotes structural and functional maturation of human brain organoids
Brain organoids derived from human pluripotent stem cells provide a highly valuable in vitro model to recapitulate human brain development and neurological diseases. However, the current systems for brain organoid culture require further improvement for the reliable production of high-quality organo...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) Sus scrofa domesticus (domestic pig) 
2021-06-02 | PXD025397 | Pride
Brain extracellular matrix Microfluidic device Organoid 
MetabolomicsThe Green Tea Modulates Large Intestinal Microbiome and Exo/Endogenous Metabolome altered through Chronic UVB-exposure (Endogenous assays)
The attenuating effects of green tea supplements (GTS) against the ultraviolet (UV) radiation induced skin damages are distinguished. However, the concomitant effects of GTS on the large intestinal microbiomes and associated metabolomes are largely unclear. Herein, we performed an integrated microbi...
2018-09-14 | MTBLS527 | MetaboLights
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