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ProteomicsMechanistic insight into the regulation of virulence factors in pathogenic E. coli by rhomboid protease GlpG
With the rise in antimicrobial resistance, understanding the virulence factors utilized by pathogenic E. coli is essential for the development of alternative therapeutics. While previous work has shown that disruption of the rhomboid protease gene glpG leads to defects in bacterial colonization, her...
ORGANISM(S): Escherichia Coli K-12 (ncbitaxon:83333) 
2025-03-06 | MSV000097249 | MassIVE
ProteomicsMechanistic insight into the regulation of virulence factors in pathogenic E. coli by rhomboid protease GlpG
Characterization of E. coli periplasmic proteins associated with bacterial virulence. In-gel digestion for proteomic changes in extracts (increased/decreased abundance) after incubation with active or inactive GlpG (n=4 each) using Orbitrap Fusion Lumos. In-gel digestion of substrates for MG1655 Glp...
ORGANISM(S): Escherichia Coli (ncbitaxon:562) 
2025-03-04 | MSV000097236 | MassIVE
UnknownA single amino acid mutation alters multiple neutralization epitopes in the respiratory syncytial virus fusion glycoprotein.
Respiratory syncytial virus (RSV) is the leading cause of infant hospitalization. All current RSV therapeutics, including antibody prophylaxis and adult vaccination, target the RSV fusion glycoprotein (RSV-F). The seven neutralization sites on RSV-F are highly conserved and infrequently mutate. Here...
S-EPMC12015481 | biostudies-literature
UnknownHuman protein interaction networks of ancestral and variant SARS-CoV-2 in organ-specific cells and bodily fluids.
Understanding SARS-CoV-2 human protein-protein interactions (PPIs) and the host response to infection is essential for developing effective COVID-19 antivirals. However, how the ancestral virus and its variants remodel virus-host protein assemblies in various organ-specific cells and bodily fluids r...
S-EPMC12219648 | biostudies-literature
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